ArticleMolecular therapy. Nucleic acids2025
Pan-cancer neural regulation pattern with implications for patient stratification and immunotherapy.
Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Cancer Neuroscience: From Local Neuro-Immune Microenvironments to Systemic Brain-Body Circuitry.MedComm · 2026Review
- Neural regulation of cancer: from synaptic integration to neuro-immune regulation.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Bidirectional crosstalk between the nervous system and the tumour microenvironment: mechanisms, feedback loops and therapeutic opportunities.Frontiers in cell and developmental biology · 2026Review
- Investigating the impact of Sprouty-related EVH1 domain-containing protein 3 on gastric cancer prognosis and tumor microenvironments.Frontiers in oncology · 2026Article
- Inhibition of Cyclin-dependent Kinase Counteracts Neuron-promoted Bladder and Endometrial Tumorigenesis: A Systematic Analysis.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interplay between the nervous system and cancer plays a central role in regulating oncogenesis. We depict the pan-cancer landscape of neuro-tumor interactions by integration of >10,000 The Cancer Genome Atlas (TCGA) bulk and 239 pan-cancer spatial transcriptomics, in combination with 115 bulk and >120,000 single-cell checkpoint-inhibitor-treated transcriptomes. Neural signals are significantly correlated with various clinical features, and neural cancer subtypes have been characterized. High neural signals are associated with cancer-associated fibroblast infiltration and immune exclusion. Spatiotemporal transcriptome analysis reveals that tumor core regions present significantly higher neural signals and further unveils the pivotal modulators essential for tumor growth via ligand-receptor interaction networks. Neural signals are predictive biomarkers for drug treatment responses, particularly cancer immunotherapy. We constructed a comprehensive data resource Neuro_Cancer, to investigate neuro-tumor interactions in diverse cancer types. Our systematic dissection of the landscape of the neuronal regulation pattern provides a deeper understanding of tumorigenesis and potential therapeutic opportunities.
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Registered trials
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