ArticlePhysics and imaging in radiation oncology2025
Apparent diffusion coefficient as a quantitative biomarker for prostate cancer treatment response on a 1.5 Tesla magnetic resonance-linear accelerator: Impact of image registration and acquisition type.
Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Microstructure imaging of prostate cancer by diffusion MRI.Magma (New York, N.Y.) · 2026Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Diffusion-weighted magnetic resonance imaging (DW-MRI) is a quantitative biomarker for cancer detection and treatment monitoring. On magnetic resonance-linear accelerator (MR-Linac) systems, diffusion-weighted echo planar imaging (DW-EPI) suffers from geometric distortion, reducing the repeatability of apparent diffusion coefficient (ADC) measurements. This study evaluated the effect of low-distortion split acquisition of fast spin-echo signal (SPLICE) sequences, and of image registration on the repeatability coefficient (RC) of ADC. Materials and methods: ADC bias, repeatability, signal-to-noise ratio (SNR) and geometric fidelity were measured in a diffusion phantom using three DW-EPI and two DW-SPLICE protocols. ADC short-term and long-term RCs were measured in healthy volunteers. In patients, the registration of DW-EPI to unweighted images (b0) was tested for its effect on RC in gross tumour volume (GTV) and non-tumour prostate (NT-P), and for its ability to detect significant ADC changes. Results: Phantom experiments showed strong linear correlation with ground-truth ADC (R Conclusion: RC and accuracy of DW-EPI agrees with published literature and improves after registration. DW-SPLICE shows lower geometric distortion but would require further optimization and validation to improve repeatability.
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