Evidence map›Paper›PMID 41146956›Full record

ArticleGlobal advances in integrative medicine and health

A Randomized Trial Testing a Novel Mind and Body Intervention for Depression: Cognitive Behavioral Therapy (CBT) and Whole-Body Hyperthermia (WBH).

Ashley E Mason, Wendy Hartogensis, Anoushka Chowdhary, Chelsea J Siwik, Leena S Pandya, Erika Jung, Osnat Lupesko-Persky, Erin Hartley, Lindsey Hopkins, Stefanie Roberts and 7 more

3 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global advances in integrative medicine and health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05708976 nacompletednot on this map

HypErthermia as an Additional Treatment for the Biology and Experience of Depression: Study 2

TypeinterventionalSponsorUniversity of California, San FranciscoRan2023 to 2024Enrolled30ConditionsMajor Depressive Disorder, DepressionArmsCognitive Behavioral Therapy (CBT), Active Whole-Body Hyperthermia (Active WBH), Sham Whole-Body Hyperthermia (Sham WBH)
NCT07564440 naenrolling by invitationnot on this map

Clinical and Biological Safety Study of the BTT Hyperthermia in Adult Subjects

TypeinterventionalSponsorMarc AbreuRan2026 to 2026Enrolled20ConditionsSafety StudyArmsHyperthermia
NCT07596914 nanot yet recruitingnot on this map

Assessing Multi-site Feasibility of an Integrated Whole-body Hyperthermia and Behavioral Intervention for Major Depressive Disorder: The MULTIBED Study

TypeinterventionalSponsorUniversity of California, San FranciscoRan2026 to 2029Enrolled60ConditionsMajor Depressive DisorderArmsCognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ashley E MasonOsher Center for Integrative Health, University of California, San Francisco (UCSF), San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-8744-0185
Wendy HartogensisOsher Center for Integrative Health, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Anoushka ChowdharyDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Chelsea J SiwikDepartment of Wellness and Preventive Medicine, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0003-1417-8582
Leena S PandyaOsher Center for Integrative Health, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Erika JungOsher Center for Integrative Health, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Osnat Lupesko-PerskyOsher Center for Integrative Health, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Erin HartleyOsher Center for Integrative Health, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Lindsey HopkinsOsher Center for Integrative Health, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Stefanie RobertsOsher Center for Integrative Health, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Jenna BorovinskyOsher Center for Integrative Health, University of California, San Francisco (UCSF), San Francisco, CA, USA.
J Craig NelsonWeill Institute for Neurosciences, University of California San Francisco (UCSF), San Francisco, CA, USA.
Christopher A LowryDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Rhonda P PatrickFoundMyFitness, LLC, San Diego, CA, USA.
Patricia J MoranOsher Center for Integrative Health, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Charles L RaisonDepartment of Psychiatry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Frederick M HechtOsher Center for Integrative Health, University of California, San Francisco (UCSF), San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-5782-1171

Funding

Training Researchers in Clinical Integrative Medicine (TRIM) - NOSI supplementT32AT003997 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHELLEY R ADLER, MARIA T CHAO · 2007 to 2026
$6.6M
Optimizing an integrated whole-body hyperthermia and behavioral intervention for major depressive disorderR34AT011221 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HECHT, FREDERICK M, MASON, ASHLEY E. · 2021 to 2023
$727k
A Daily, Digital Mindfulness-Based Intervention for Depressive Symptoms After Serious IllnessK23AT012484 · NCCIH · CLEVELAND CLINIC LERNER COM-CWRU · PI Chelsea Jane Siwik · 2025 to 2026
$406k
NCCIH NIH HHS K23 AT012484NCCIH NIH HHS L30 AT011624NCCIH NIH HHS R34 AT011221NCCIH NIH HHS T32 AT003997
6 · The paper itself

Abstract

Objective: To assess the acceptability of a randomized single-blind trial of cognitive behavioral therapy (CBT) and whole-body hyperthermia (WBH) treatment for major depressive disorder (MDD). Methods: All participants (N = 30) with MDD received CBT for depression and were randomized to also receive either: (1) WBH that raised core body temperature using an infrared sauna device, or (2) sham WBH of a similar duration that did not significantly raise core body temperature. Results: Study acceptability was the primary outcome: of participants who completed the final assessment (n = 29; 96.7%), 22 (75.9%) reported that they would recommend participation to a friend or family member with MDD. Twenty-five (86.2%) participants reported that they would be Conclusions: Study procedures were acceptable. Participants in the WBH and sham WBH groups had substantial reductions in depressive symptoms that were greater than typically seen with CBT alone. The sham WBH arm was not fully credible and may have exerted antidepressant effects, thus raising concerns about its use in future trials. Further research to test whether adding WBH to CBT results in additional antidepressant effects is warranted.

Indexed as

cognitive behavioral therapymajor depressive disorderwhole-body hyperthermia

Identifiers

PMID41146956
PMCPMC12553885

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.