Evidence map›Paper›PMID 41146953›Full record

ReviewIBRO neuroscience reports2025

Lithium-induced neuroprotection in bipolar disorder: Translational insights into cytoskeletal and proteomic mechanisms.

Muthusamy Thangavel, T Sterlin Raj, Sasikala Chinnappan, Muralidharan Anbalagan, Narasingam Arunagirinathan, Edal Kuvin, Pattabi Sasikumar, Chitraabaanu Paranjothy, Ravishankar Ram Mani

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muthusamy ThangavelCellular and Molecular Biochemistry, Research and Development Wing, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research (BIHER), Chromepet, Chennai, Tamil Nadu 600044, India.
T Sterlin RajDepartment of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University, Cheras, Kuala Lumpur 56000, Malaysia.
Sasikala ChinnappanDepartment of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University, Cheras, Kuala Lumpur 56000, Malaysia.
Muralidharan AnbalaganDepartment of Structural & Cellular Biology, Tulane University School of Medicine, New Orleans, LA, USA.
Narasingam ArunagirinathanCentral Research Laboratory, Meenakshi Academy of Higher Research and Education (Deemed to be University), Chennai, India.
Edal KuvinDepartment of Psychiatric Nursing, Bethel College of Nursing, Ranchi, Jharkhand State, India.
Pattabi SasikumarDepartment of General Surgery, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research (BIHER), Chromepet, Chennai, Tamil Nadu 600044, India.
Chitraabaanu ParanjothyKlinik Chong (Medicruz Sdn. Bhd), No:55, 2nd Floor, Bangunan Eng Choon, Jalan Ampang, Kuala Lumpur 50450, Malaysia.
Ravishankar Ram ManiCellular and Molecular Biochemistry, Research and Development Wing, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research (BIHER), Chromepet, Chennai, Tamil Nadu 600044, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pharmacotherapy of lithium plays mainstay in the modulation of bipolar disorder (BD) and controls other neuropsychiatric conditions such as prophylactic and mood episodes. However, its neurotrophic properties embrassing hypothetically converged synaptic regulation to BD remains elusive. Several studies intricate evidence of lithium targetting 'microtubular associated protein-2 (MAP2)' to endure neuroprotection. Synthesis of multiple single nucleiotide gene polymorphisms of

Indexed as

Bipolar DisorderCytoskeletal ProteinsDepressionLithiumMood episodesNeurodegeneration

Identifiers

PMID41146953
PMCPMC12554221

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.