Evidence map›Paper›PMID 41146933›Full record

ArticleTherapeutic advances in neurological disorders2025

Access, satisfaction, adherence and safety to subcutaneous natalizumab compared to intravenous natalizumab in multiple sclerosis in a real-life cohort: first report from Latin America.

Berenice A Silva, Franco Santajuliana, Magdalena Casas, Luciana Lázaro, Cecilia Pita, Leila Cohen, Guido Rinaldi, Ricardo Alonso, Jimena Míguez, Sofía D'Alessandro

Abstract read
In one paragraph

Article in Therapeutic advances in neurological disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Berenice A SilvaSección Esclerosis Múltiple y enfermedades desmielinizantes, Hospital Italiano de Buenos Aires, Peron 4190, Argentina CUEM, Hospital Ramos Mejía, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0001-5866-2419
Franco SantajulianaSección Esclerosis Múltiple y enfermedades desmielinizantes, Hospital Italiano de Buenos Aires, Argentina.
Magdalena CasasCUEM, Hospital Ramos Mejía, Buenos Aires, Argentina.
Luciana LázaroCUEM, Hospital Ramos Mejía, Buenos Aires, Argentina.
Cecilia PitaCUEM, Hospital Ramos Mejía, Buenos Aires, Argentina.
Leila CohenCUEM, Hospital Ramos Mejía, Buenos Aires, Argentina.
Guido RinaldiHospital San Martin De La Plata, Buenos Aires, Argentina.
Ricardo Alonso
Jimena MíguezSección Esclerosis Múltiple y enfermedades desmielinizantes, Hospital Italiano de Buenos Aires, Argentina.
Sofía D'AlessandroSección Esclerosis Múltiple y enfermedades desmielinizantes, Hospital Italiano de Buenos Aires, Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Subcutaneous natalizumab (scN) was recently approved in Argentina for people with multiple sclerosis (pwMS). The impact of this change in this population is unknown. Objectives: To evaluate the use, access and satisfaction of scN and correlate it with clinical and demographic variables. Desing: cross-sectional study was conducted, surveying pwMS who received scN and ivN from public and private MS Centres since its approval. Methods: Treatment adherence was assessed using the MS Treatment Adherence Questionnaire (MS-TAQ) and satisfaction using Treatment Satisfaction of Questionnaire for Medication (TSQM). Clinical and demographic variables were also recorded. Results: 84 pwMS were included, 58.3% female, mean EDSS: 2.4 ± 1.2, mean age: 34.8 ± 10.8 years, mean disease duration: 7.8 ± 4.5 years, mean time under Conclusion: We found a high rate of change to scN from ivN, associated with a higher score in the comfort and convenience items in people receiving scN, compared to ivN. Access barriers should be addressed in order to improve treatment comfort.

Indexed as

accessadherencemultiple sclerosisnatalizumabsatisfactionsubcutaneoustreatment

Identifiers

PMID41146933
PMCPMC12553923

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.