ArticleEClinicalMedicine2025
Association between adherence to cancer prevention guidelines and cancer risk: a comprehensive systematic review and dose-response meta-analysis of cohort studies.
Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cancer prevention and screening for people with intellectual disabilities in Europe: a systematic review and recommendations for policy and practice.Frontiers in public health · 2026Pooled it
- Association between adherence to cancer primary prevention recommendations and multimorbidity among a cohort of British Columbians.Journal of multimorbidity and comorbidityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: No systematic review and meta-analysis has comprehensively assessed the association between adherence to major cancer prevention guidelines and risks of cancers in cohort studies. We aimed to evaluate the associations of adherence to the 2018 and the 2007 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and the 2012 American Cancer Society (ACS) guidelines with risks of multiple cancer outcomes. Methods: This systematic review and meta-analysis was conducted by searching cohort studies across PubMed, Web of Science, Embase, and Scopus, from database inception to July 31, 2025. We assessed associations between adherence to the three major global cancer prevention guidelines: the 2018 WCRF/AICR guidelines, the 2007 WCRF/AICR guidelines, and the 2012 ACS guidelines, and the risk of total cancer, obesity-related cancer, and 13 site-specific cancers (Colorectal, Breast, Lung, Prostate, Bladder, Kidney, Stomach, Pancreas, Esophagus, Liver, Ovary, Uterus, Gallbladder). Hazard ratios (HRs) with 95% confidence intervals (CIs) were extracted to evaluate risks of cancers. DerSimonian and Laird random-effects models were used to pool effect sizes, and the Findings: This study comprised 28 cohort articles, examining 15 cancer types for quantitative analysis and 15 additional cancer types for qualitative analysis. It revealed that adherence to cancer prevention guidelines was associated with a significant 14% reduction in total cancer risk (HR = 0.86, 95% CI: 0.83-0.88, Interpretation: Adherence to cancer prevention guidelines was associated with reduced risks of total cancer and multiple major cancers, while no significant associations were observed for prostate cancer or ovarian cancer. These findings reinforce the importance of integrating cancer prevention guidelines into public health strategies for cancer prevention. Further research is warranted to elucidate associations of 2018 WCRF/AICR with risk of a broader spectrum of cancers, particularly in Asian populations. Funding: This research was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government through the Ministry of Science and ICT (MSIT) (grant number: RS-2025-00556573).
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