ArticleOrthopaedic journal of sports medicine2025
10-Year Clinical and MRI-Based Outcomes of a Randomized Controlled Trial Evaluating a 6-Week Return to Full Weightbearing After Matrix-Induced Autologous Chondrocyte Implantation.
Article in Orthopaedic journal of sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Knee osteoarthritis management across the joint-preservation continuum: current evidence and future directions.Frontiers in surgery · 2026Review
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Authors and funding
6 authors.
Funding
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Abstract
Background: Matrix-induced autologous chondrocyte implantation (MACI) has demonstrated encouraging outcomes in treating symptomatic knee cartilage lesions. Rehabilitation is imperative to optimize outcome, although it has been traditionally conservative. Purpose: To investigate the longer term clinical and radiological outcome of MACI and investigate any differences in outcome between patients randomized to a 6-week (vs 8-week) return to full weightbearing (WB) after MACI. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A total of 35 patients were recruited into the study, though 37 knees (i.e. two patients had both knees inlcuded at different timepoints) were independently evaluated preoperatively and at 1, 2, 5, and 10 years after surgery. A comparison was made between recruited knees prospectively randomized to a 6-week (n = 18) or 8-week (n = 19) return to full WB after MACI. Patient-reported outcome measures (PROMs) were assessed utilizing the Knee injury and Osteoarthritis Outcome Score. Peak isokinetic knee extensor and flexor torque and single-leg hop capacity (single horizontal, lateral, and medial hop tests for distance) were assessed, with limb symmetry indices (LSIs) calculated. High-resolution magnetic resonance imaging (MRI) was undertaken at all postoperative time points to assess pertinent parameters of graft integrity as per the MOCART (magnetic resonance observation of cartilage repair tissue) system. A combined MRI composite score was also evaluated. Results: At 10 years after surgery, 31 knees (84%) were available for review, with 3 knees (6 weeks, n = 2; 8 weeks, n = 1) lost to follow-up and 3 knees (6 weeks, n = 1; 8 weeks, n = 2) having already had total knee arthroplasty (TKA) performed before 10 years. All PROMs (apart from the Mental Component Summary of the 36-item Short Form Health Survey [ Conclusion: MACI provided sustained clinical and MRI-based outcomes in most patients to 10 years after surgery, with high satisfaction levels. The 6-week WB protocol did not jeopardize the early or longer term graft outcome.
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