ArticleCureus2025
Sonographic Predictors and Outcomes of Second-Dose Misoprostol in Early Pregnancy Loss.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMisoprostol is a preferred medical agent for managing early pregnancy loss. However, the optimal protocol, particularly repeat dosing, remains a topic of debate.
objectiveTo evaluate the effectiveness of a second dose of misoprostol in women with incomplete uterine evacuation after the first dose, and to examine sonographic findings and demographic data to identify factors associated with successful treatment.
methodsRetrospective descriptive study of electronic medical records from a tertiary university-affiliated hospital. We identified women who had early pregnancy loss and received a second dose of misoprostol vaginally after an incomplete response to the first dose.
resultsA second dose of misoprostol achieved a 49% success rate for uterine evacuation without surgical intervention. Demographic and obstetric characteristics were similar in both the intervention and non-intervention groups; 44% of delayed miscarriages and 49% of anembryonic pregnancies with an intact sac persisted after the second dose (p<0.001). Delayed miscarriage and anembryonic pregnancy after the first dose significantly increased the odds of surgical intervention (delayed miscarriage: odds ratio (OR) 4.138, 95% confidence interval (CI) 1.513-11.317; anembryonic pregnancy: OR 2.921, 95% CI 1.349-6.326).
conclusionA second dose of misoprostol offers effective care. Sonographic results after the first dose help forecast the need for surgical intervention.
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