ReviewCureus2025
Infective Endocarditis in Special Populations: Epidemiology, Diagnostic Challenges, and Management Strategies.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Phenotype-Based Stratification and Early Prediction of Staphylococcal Infective Endocarditis: Development of a Pragmatic Bedside Score.Pathogens (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infective endocarditis (IE) remains a severe cardiovascular infection with persistently high morbidity and mortality despite advances in antimicrobial therapy, imaging, and surgical techniques. Its burden is disproportionately borne by special populations, including patients with prosthetic or transcatheter valves, people who inject drugs, pregnant women, individuals with congenital heart disease, immunocompromised hosts, and critically ill patients. These groups face distinct epidemiological patterns, atypical clinical presentations, and complex management challenges that diverge from native valve disease. We conducted a comprehensive literature review across PubMed/MEDLINE, Web of Science, and Scopus, ultimately including 57 studies addressing epidemiology, diagnostic approaches, surgical management, and outcomes in special populations. Findings highlight increased susceptibility due to prosthetic material, injection practices, immunosuppression, and pregnancy-related physiological changes, as well as diagnostic delays stemming from atypical features or imaging limitations. Management requires balancing infection control with patient-specific risks, including maternal-fetal safety, recurrent infections, or frailty in transplant and ICU patients. Outcomes across groups remain poor, underscoring the need for tailored multidisciplinary strategies. Future directions include refined risk stratification tools, wider adoption of advanced imaging modalities, integration of harm reduction and preventive approaches, and establishment of registries to generate high-quality data in underrepresented populations. By synthesizing current evidence, this review emphasizes the necessity of individualized strategies to improve care and prognosis for vulnerable patients with IE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.