Evidence map›Paper›PMID 41146753›Full record

ArticleCureus2025

Mucosal Fibrosis on Biopsy Predicting Intestinal Perforation in Adult-Onset IgA Vasculitis: A Case Report.

Shoichi Yoshinaga, Ryota Sakai, Akiko Shibata, Takahiko Kurasawa, Koichi Amano

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shoichi YoshinagaRheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JPN.
Ryota SakaiRheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JPN.
Akiko ShibataRheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JPN.
Takahiko KurasawaRheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JPN.
Koichi AmanoRheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of adult-onset IgA vasculitis that required surgery due to the perforation of the jejunum despite treatment with high-dose glucocorticoids and resolution of the inflammatory response. A mucosal biopsy before treatment revealed only localized fibrosis, while surgical pathology demonstrated ulceration and perforation with extensive submucosal fibrosis at the same site. These findings suggest that mucosal fibrotic changes observed on biopsy may indicate a risk of perforation and support the early use of cyclophosphamide or other agents for refractory disease.

Indexed as

biopsyfibrosisiga vasculitisintestinal perforationpathology

Identifiers

PMID41146753
PMCPMC12554004

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.