Evidence map›Paper›PMID 41146729›Full record

ArticleJournal of Alzheimer's disease reports

Comparison of microglial cell population expansion in the

Julie Hansen, Rowda Mohamed, Laura Ilkjær, Thomas Krøigård, Mithula Sivasaravanaparan, Malene P Stoico, Alicia A Babcock, Mark J West, Ove Wiborg, Bente Finsen

Abstract read
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In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julie HansenDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Rowda MohamedDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Laura IlkjærDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Thomas KrøigårdDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0002-1565-6948
Mithula SivasaravanaparanDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Malene P StoicoDepartment of Molecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark.ORCID https://orcid.org/0009-0006-0213-6528
Alicia A BabcockDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Mark J WestDepartment of Neurobiology, Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Ove WiborgDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Bente FinsenDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0002-8323-9329

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic microglial activation is a key characteristic of Alzheimer's disease (AD). In mouse models of AD, microglial activation is considered associated with microglial cell population expansion. Objective: To elucidate species- and gene-dosage-dependent differences and similarities in microglial cell population expansion in response to amyloid-β (Aβ) plaque pathology. Methods: The total number of Iba1 Results: A significant two-fold increase in microglia was observed in the neocortex of hemizygous Conclusions: Transgenic mouse and rat AD models show significant differences in microglial population expansion, with a more restrained expansion in the rat. However, in both species and regardless of gene-dosage, population expansion is preceded by microglial clustering around Aβ plaques, indicating that cluster-formation is a key event in AD neuropathology.

Indexed as

Alzheimer's diseaseamyloid-betamicrogliamicroglial clusters

Identifiers

PMID41146729
PMCPMC12553888

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.