ArticleThe Lancet regional health. Western Pacific2025
Cardiovascular complications in acute dengue infection: a population-based cohort study.
Article in The Lancet regional health. Western Pacific, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Research progress on the association between viruses and cardiac diseases.Journal of virology · 2026Review
- Article
- Arrhythmias in Dengue: Moving Upstream from Electrocardiographic Findings to Cardio-Hemodynamic Dysfunction. Comment on López-Delgado et al. Arrhythmias in Dengue: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2026Article
- Dual Infection with dengue virus and infective endocarditis leading to brain abscess, multiorgan infarctions, and horner syndrome: a case report with literature review.BMC cardiovascular disorders · 2026Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute dengue-virus (DENV) infection, while associated with mild disease in most instances, is anecdotally associated with more severe cardiovascular complications. However, more accurate estimates of cardiac complications are required to evaluate the actual burden of dengue-associated morbidity, given significant contribution of cardiovascular events to overall morbidity and rising incidence of DENV-infection attributable to climate change. Methods: A population-based cohort of DENV-infected Singaporean adults (2017-2023) and population-based controls (without DENV-infection) was constructed using the national-dengue-registry. Overlap weights were employed to balance baseline covariates. Logistic regression was used to estimate odds of cardiovascular events in DENV-infected cases versus uninfected controls up to 30 days from T Findings: 65,207 DENV-infected cases and 1,616,865 uninfected controls were included. Higher odds of any cardiovascular event (adjusted-odds-ratio, aOR = 10.63 [95% CI = 7.56, 15.48]), major-adverse-cardiac-event (MACE) (aOR = 2.92 [95% CI = 1.81-4.88]), dysrhythmia (aOR = 18.44 [95% CI = 11.25 = 32.96]) and ischemic-heart-disease (aOR = 3.00 [95% CI = 1.83-5.15]) were observed up to 30 days post-DENV-infection, versus uninfected controls. Odds of acute cardiovascular events remained higher in both ambulatory/hospitalised DENV-infected cases, DENV-IgG-positive/negative cases, and across DENV1/2 and DENV3-predominant transmission, versus uninfected controls. However, overall excess burden (EB) of acute cardiovascular events in DENV-infected adults was modest, with <1 excess event per-100-cases except amongst those aged ≥60 years (EB = 1.25 [95% CI = 1.05-1.44]). Interpretation: Acute DENV-infection was associated with higher odds of cardiovascular events up to 30 days post-infection; though excess-burden was modest. Older adults at higher risk should be monitored for cardiac complications following acute DENV-infection. Funding: National-Medical-Research-Council, Singapore.
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