ArticleMaterials today. Bio2025
Selenium-functionalized hyaluronic acid dissolvable microneedle patch synergistic herbal shikonin-loaded tetrahedral framework nucleic acids for psoriasis therapy.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Hydrogel microneedles functioning in pathological surroundings: where soft materials overcome hard scars.Materials today. Bio · 2026Review
- Can Microneedle-Nanocarrier Platforms Deliver True Tolerogenic Immunotherapy for Psoriasis?Vaccines · 2026Review
- Dissolving microneedle delivery of anemoside B4: a strategy to enhance therapeutic efficacy against psoriasis.Drug delivery and translational research · 2026Article
- Article
- From Bioactive Selenium Nanoparticles to Multifunctional Dermatological Platforms: Mechanism-Guided Design and Translational Challenges.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psoriasis is a complex, chronic inflammatory skin disease for which current therapies are limited by systemic toxicity, rapid relapse, and incomplete resolution. Despite advances in microneedle (MN)-assisted transdermal drug delivery, conventional systems often suffer from suboptimal pharmacokinetics and limited therapeutic versatility. Here, we engineered a dissolvable MN patch composed of selenium-functionalized hyaluronic acid (SeHA) integrated with shikonin-loaded tetrahedral framework nucleic acids (SFN) to enable sustained drug release while modulating the reactive oxygen species (ROS)-rich psoriatic microenvironment. The SeHA-SFN MNs exhibited robust mechanical properties, permitting efficient penetration of hyperkeratotic epidermis, followed by rapid dissolution and targeted SFN delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.