Evidence map›Paper›PMID 41146661›Full record

ArticleMaterials today. Bio2025

Tea-derived extracellular vesicles-mediated PDRN delivery activates cAMP-HIF-1α to restore intestinal homeostasis in inflammatory bowel disease.

Tingting Cao, Runrun Wan, Xueru Li, Xin Hu, Chengbiao Hu, Yan Liang, Meng Deng, Xiangdong Wang, Zhang Yuan, Chenghu Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Extracellular Vesicles Derived fromNanomaterials (Basel, Switzerland) · 2026
    Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tingting CaoXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Beilin District, Xi'an, Shaanxi, 710072, PR China.
Runrun WanXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Beilin District, Xi'an, Shaanxi, 710072, PR China.
Xueru LiXi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, Shaanxi, 710032, PR China.
Xin HuKey Laboratory of Fu Tea Processing and Utilization, Ministry of Agriculture and Rural Affairs, Xianyang, Shaanxi, 712044, PR China.
Chengbiao HuXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Beilin District, Xi'an, Shaanxi, 710072, PR China.
Yan LiangKey Laboratory of Fu Tea Processing and Utilization, Ministry of Agriculture and Rural Affairs, Xianyang, Shaanxi, 712044, PR China.
Meng DengXi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, Shaanxi, 710032, PR China.
Xiangdong WangXi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, Shaanxi, 710032, PR China.
Zhang YuanXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Beilin District, Xi'an, Shaanxi, 710072, PR China.
Chenghu HuXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Beilin District, Xi'an, Shaanxi, 710072, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical translation of polydeoxyribonucleotide (PDRN), a bioactive agent with anti-inflammatory and tissue-repair properties, is hindered by significant oral delivery barriers. This study utilizes inflammatory bowel disease (IBD) as a disease model, which is characterized by a vicious cycle of excessive oxidative stress, immunological homeostasis imbalance and intestinal flora dysbiosis in the colon. Leveraging the targeted delivery advantages of tea-derived extracellular vesicles (EV), we have developed them as nanocarriers to overcome the oral delivery challenges of PDRN (PDRN-EV). PDRN-EV exhibits excellent structural stability under simulated gastrointestinal conditions.

Indexed as

Inflammatory bowel diseaseMulti-mechanism coordinationOral administrationPolydeoxyribonucleotideTea-derived extracellular vesicles

Identifiers

PMID41146661
PMCPMC12554201

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.