Evidence map›Paper›PMID 41146659›Full record

ArticleMaterials today. Bio2025

Sequentially regulated immuno-osteogenic bioceramics enhance the regeneration of osteoporotic bone defects.

Yan Yang, Jiaqian Zheng, Qiji Lu, Yudi Kuang, Jingjing Diao, Naru Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yan YangSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Jiaqian ZhengSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Qiji LuNational Engineering Research Centre for Tissue Restoration and Reconstruction, Guangzhou, 510006, China.
Yudi KuangSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Jingjing DiaoNational Engineering Research Centre for Tissue Restoration and Reconstruction, Guangzhou, 510006, China.
Naru ZhaoSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sequentially regulating immune-osteogenesis to orderly transition from the inflammatory phase to bone reconstruction, and enhancing bone regeneration while inhibiting osteoclastic resorption, are crucial for the treatment of osteoporotic bone defect. Herein, the sequential loading and controlled release of interleukin-4 (IL-4) and alendronate (AL) based on the 3D-printed β-tricalcium phosphate (β-TCP) scaffolds were achieved via the Michael addition reaction combined with physical adsorption. IL-4 was rapidly released within two days, promoting M2 polarization of macrophage and secretion of anti-inflammatory and osteogenesis-associated factors. Meanwhile

Indexed as

Bone regenerationImmune-osteogenesisOsteoporotic bone defectSequential regulation

Identifiers

PMID41146659
PMCPMC12554199

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.