Prediction of Episodic Memory With Multiomics Scores.

Anni L K Malmberg, Matti Pirinen, Johannes Kettunen, Katri Räikkönen, Johan G Eriksson, Jari Lahti

Abstract read

In one paragraph

Article in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anni L K MalmbergDepartment of Psychology, University of Helsinki, Helsinki, Finland.

Matti PirinenDepartment of Mathematics and Statistics, University of Helsinki, Helsinki, Finland.

Johannes KettunenSystems Epidemiology, Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.

Katri RäikkönenDepartment of Psychology, University of Helsinki, Helsinki, Finland.

Johan G ErikssonFolkhälsan Research Centre, Helsinki, Finland.

Jari LahtiDepartment of Psychology, University of Helsinki, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Episodic memory (EM) refers to the ability to encode and recall events-a vital cognitive function for healthy cognitive aging and an endophenotype for dementia. Methods: Using genome- and metabolome-wide least absolute shrinkage and selection operator (LASSO) analysis, we developed polygenic (LASSO-PRS) and metabolic risk scores (MRS) in ∼68.5-year-old individuals ( Results: In the independent sample of ∼68.5-year-old individuals, compared with CAIDE score alone, accounting additionally for either MRS, LASSO-PRS, or GWAMA-PRS increased Conclusions: Genomics added predictive value to EM beyond epidemiological risk factors in adults, but the same was not observed with metabolomics. Adult-derived PRSs did not predict EM in children.

Indexed as

Episodic memoryGenome-wide association analysisMetabolome-wide association analysisMultiomicsNeurocognitionPrediction

Identifiers

PMID41146645

DOI10.1016/j.bpsgos.2025.100607

PMCPMC12554030

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.