Bloodstream infections in Cameroon: a systematic review and meta-analysis.

Background: Bloodstream infections (BSIs) are significantly associated with morbidity and mortality worldwide, and particularly in low-resource settings. We determined the prevalence of BSIs, profile, and antimicrobial resistance of the causing bacteria in Cameroon. Methods: PubMed, Google Scholar and ScienceDirect databases were searched to identify relevant studies. The random or fixed effect model was used depending on the level of heterogeneity among studies for pooling estimates after the variance was stabilised through the Freeman-Tukey double arcsine transformation. Begg's and Egger's tests were used to quantify publication bias. The protocol was registered in PROSPERO (CRD42023482760). Results: The analysis of 5680 blood cultures from ten studies revealed an overall bacterial BSI prevalence of 25.2 % (95 % CI: 18.1-33.2 %) and 17.2 % (11.6-23.7 %) when the potential contaminants were removed. The leading BSI-causing bacteria were Conclusion: This study reports a substantial prevalence of BSI and resistance to the commonly used antibiotics. It also points out the lack of compliance with international guidelines in microbiological analysis. This highlights the need to empower laboratories' capacities and conduct BSI surveillance across the country to develop more targeted strategies for the prevention, management and treatment of BSIs.