ArticlePhysiological reports2025
Association between caffeine and the eGFR dip after initiation of SGLT2 inhibitors in adult patients.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Association between caffeine and the eGFR dip after initiation of SGLT2 inhibitors in adult patients.Physiological reports · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are cornerstone therapies for heart failure and chronic kidney disease. Clinical trials have demonstrated that the estimated glomerular filtration rate (eGFR) typically declines within the first few weeks after SGLT2i initiation. One proposed mechanism of the acute eGFR dip is the reduced intraglomerular pressure through tubuloglomerular feedback (TGF). Adenosine is a key mediator in TGF signaling, and caffeine, a nonselective adenosine receptor antagonist, may influence this process. We conducted a retrospective cohort study at SSM Health Saint Louis University Hospital to examine whether caffeine intake influences the initial eGFR dip following SGLT2i initiation. Eligible patients completed a caffeine consumption survey, and chart reviews assessed creatinine and proteinuria at baseline and 1 month post-initiation. Data from 62 patients (mean age 60.1 ± 12.4 years; median eGFR 50.0 [IQR 37.2-66.9] mL/min/1.73 m
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