Evidence map›Paper›PMID 41146465›Full record

ArticlePediatric blood & cancer2026

Shared Sociodemographic Risk Factors for Neurocognitive Dysfunction in Children With Cancer and Blood Disorders.

Claire E F Miller, Jamie Neiman Luehring, Elizabeth B Molina Kuna, Shweta Bhatia, Adam L Green, Bruce E Compas

Abstract read
In one paragraph

Article in Pediatric blood & cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Claire E F MillerDivision of Pediatric Hematology, Oncology, and Bone Marrow Transplant, Department of Pediatrics, Primary Children's Hospital, University of Utah, Salt Lake City, Utah, USA.
Jamie Neiman LuehringCenter For Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, Colorado, USA.
Elizabeth B Molina KunaPopulation Health Shared Resource, University of Colorado Cancer Center, Aurora, Colorado, USA.
Shweta BhatiaDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Adam L GreenCenter For Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, Colorado, USA.
Bruce E CompasDepartment of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee, USA.

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Paul Calabresis Award in Clinical Oncology ResearchK12CA086913 · NCI · UNIVERSITY OF COLORADO DENVER · PI VIRGINIA F. BORGES, Jill E Slansky · 2000 to 2026
$17.8M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
NCI NIH HHS K12 CA086913NCI NIH HHS P30 CA046934NICHD NIH HHS P50 HD103537
6 · The paper itself

Abstract

backgroundTo investigate the role of social determinants of health (SDoH) in neurocognitive functioning among children with acute lymphoblastic leukemia (ALL), central nervous system (CNS) tumors, and sickle cell disease (SCD). PROCEDURE: Fifty-eight child-caregiver dyads participated. SDoH included components of socioeconomic status (SES; family income, caregiver education, and insurance type), race/ethnicity, caregiver marital status, and neighborhood-level deprivation. Neurocognitive functioning was measured using the NIH Toolbox Cognition Battery (NIHTB-CB) Fluid Cognition subtests.

resultsThere were no differences in SDoH between the three diagnosis groups other than expected differences in race/ethnicity (χ

conclusionsLower family income emerged as an important element of SES associated with poorer neurocognitive functioning in children treated for cancer and blood disorders. Further research is needed to determine how family income alters neurocognitive functioning, whether by altering the timing of emergence or the magnitude of deficits. Future studies should investigate mechanisms linking low income to neurocognitive performance to inform interventions to bolster neurocognitive development.

Indexed as

Anemia, Sickle CellCentral Nervous System NeoplasmsNeurocognitive DisordersPrecursor Cell Lymphoblastic Leukemia-LymphomaSocial Determinants of HealthAdolescentChildChild, PreschoolFemaleFollow-Up StudiesHumansMaleNeuropsychological TestsRisk FactorsSociodemographic FactorsSocioeconomic Factorsneurocognitive functionpediatric hematology/oncologypsychosocialsocial determinants of health

Identifiers

PMID41146465
PMCPMC12890220

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.