Observational studyBMJ open2025
Association between coronary artery calcium and the progression of calcific aortic valve disease: a hospital population-based observational retrospective cohort study.
Observational study in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Evidence of different predictors for different types of cardiotoxicities after hypo-fractionated whole breast radiotherapy.Frontiers in oncology · 2026Article
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9 authors.
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Abstract
objectivesTo explore the association between the degree of coronary artery calcium (CAC) and the progression of calcific aortic valve disease (CAVD).
designA single-centre retrospective cohort study using a hospital-based database.
participantsA total of 2898 patients who underwent coronary CT angiography and serial echocardiograms at ≥6 months apart were included. Initial echocardiography was performed within 6 months from the time of CCTA. OUTCOME MEASURES: CAC was divided into four groups: 0, 1-99, 100-399 and ≥400 (Agatston units, AU). The progression of CAVD was defined in two ways: progression 1 as at least one grade of progression, progression 2 as at least moderate aortic stenosis (AS) at follow-up.
resultsAt the initial CAVD grade, patients with at least mild AS tended to increase with increasing CAC (p<0.001). During a median follow-up of 3.2 years (IQR, 1.8-5.0 years), 101 patients (3.5%) experienced progression 1 and 24 patients (0.8%) suffered progression 2. There was a statistically significant increase in risk of progression 1 in CAC 100-399 and ≥400 groups than CAC 0 and 1-99 groups (p<0.001). In progression 2, the CAC≥400 group showed a higher progression rate than the other groups (p<0.001). In multivariable logistic regression, age (adjusted OR (aOR), 1.06; 95% CI, 1.02 to 1.09; p=0.001), CAC≥400 (aOR, 2.55 vs CAC 0 as a reference group; 95% CI, 1.19 to 5.46; p=0.016), body mass index (aOR, 1.09; 95% CI, 1.02 to 1.17; p=0.010) and initial peak aortic jet velocity (aOR, 1.21 per 0.1 m/s increase; 95% CI, 1.14 to 1.28; p<0.001) were associated with progression 1. In progression 2, CAC≥400 (aOR, 44.5 vs CAC 0 as a reference group; 95% CI, 1.09 to 1810; p=0.045), eGFR (aOR, 0.88; 95% CI, 0.80 to 0.97; p=0.007), left ventricular mass index (aOR, 1.05; 95% CI, 1.01 to 1.10; p=0.029) and initial peak aortic jet velocity (aOR, 4.21 per 0.1 m/s increase; 95% CI, 1.86 to 9.53; p=0.001) were significant determinants.
conclusionsCAC was significantly associated with the progression of CAVD. Particularly, CAC≥400 was linked to progression toward significant AS.
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