ArticleStem cell research & therapy2025
Human induced pluripotent stem cell-derived cardiomyocytes improve recovery from myocardial infarction in non-human primates.
Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
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13 authors.
Funding
Abstract
backgroundThe transplantation of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represents a promising next-generation cell therapy for repairing injured myocardium. However, the safety, efficacy, and pharmacokinetics of these cells in non-human primates (NHPs) with myocardial infarction (MI) have not been systematically investigated.
methodsSixteen rhesus monkeys underwent MI surgery, with 10 monkeys receiving 1 × 10
resultshiPSC-CM transplantation significantly improved cardiac performance at 4 and 12 weeks after MI, including left ventricular (LV) ejection fraction, fractional shortening, end-systolic volume, and internal dimension at end-systole. Furthermore, cell transplantation reduced myocardial infarct size, reversed cardiac hypertrophy, and increased angiogenesis 12 weeks after MI. Although there was a higher incidence of arrhythmias in the cell therapy group compared to the control group, it was resolved 2 weeks after cell transplantation. The survival of multiple islands of human myocardial cells in the host hearts was identified 12 weeks after cell implantation, indicating the remuscularization potential of hiPSC-CMs. Consistent with this, PET/CT tracking of
conclusionsThe transplantation of hiPSC-CMs can effectively repair injured cardiac tissue in an NHP MI model without any adverse off-target effects. Therefore, the direct intramyocardial injection of hiPSC-CMs is a promising, effective, and safe strategy for treating MI.
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