Evidence map›Paper›PMID 41146342›Full record

ArticleActa neuropathologica communications2025

Neuronal gene profiling of tau oligomer-bearing cholinergic nucleus basalis neurons during the onset of Alzheimer's disease.

Betul Kara, John S Beck, Zhen Fu, Stephanie L Hickey, Nicholas M Kanaan, Elliott J Mufson, Stephen D Ginsberg, Scott E Counts

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Betul KaraDepartment of Translational Neuroscience, MSU Grand Rapids Research Center, Michigan State University College of Human Medicine, 400 Monroe Ave NW Ste 2008, Grand Rapids, MI, 49503, USA.
John S BeckDepartment of Translational Neuroscience, MSU Grand Rapids Research Center, Michigan State University College of Human Medicine, 400 Monroe Ave NW Ste 2008, Grand Rapids, MI, 49503, USA.
Zhen FuBioinformatics and Biostatistics Core, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA.
Stephanie L HickeyBioinformatics Core, Michigan State University, 12 Wilson Rd., East Lansing, MI, 48824, USA.
Nicholas M KanaanDepartment of Translational Neuroscience, MSU Grand Rapids Research Center, Michigan State University College of Human Medicine, 400 Monroe Ave NW Ste 2008, Grand Rapids, MI, 49503, USA.
Elliott J MufsonDepartments of Translational Neuroscience and Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, 2910 N 3rd Ave, Phoenix, AZ, 85013, USA.
Stephen D GinsbergCenter for Dementia Research, Nathan Kline Institute, 140 Old Orangeburg Rd, Orangeburg, NY, 10962, USA.
Scott E CountsDepartment of Translational Neuroscience, MSU Grand Rapids Research Center, Michigan State University College of Human Medicine, 400 Monroe Ave NW Ste 2008, Grand Rapids, MI, 49503, USA. countssc@msu.edu.

Funding

Impact of sex differences on the trajectory of interactome dysfunctions across the AD spectrumR01AG074004 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI CHIOSIS, GABRIELA, GINSBERG, STEPHEN D · 2021 to 2025
$6.0M
Selective interactome vulnerability across the Alzheimer’s disease spectrumR01AG072599 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI GABRIELA CHIOSIS, STEPHEN D GINSBERG · 2023 to 2026
$5.4M
Selective interactome vulnerability across the Alzheimer’s disease spectrumR56AG072599 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI CHIOSIS, GABRIELA, GINSBERG, STEPHEN D · 2021 to 2021
$1.2M
NIA NIH HHS R01 AG072599NIA NIH HHS R01 AG074004NIA NIH HHS R56 AG072599
6 · The paper itself

Abstract

Soluble tau oligomeric assemblies display neurotoxic properties and may provide a pathogenic link between neurofibrillary tangle evolution and selective neuronal vulnerability in Alzheimer's disease (AD). However, the precise molecular and cellular pathways mediating tau oligomer toxicity are unclear. We combined single-neuron laser capture microdissection with custom microarrays to investigate differences in the molecular signatures of basal forebrain neurons within the nucleus basalis of Meynert (nbM) labeled for p75

Indexed as

Alzheimer DiseaseBasal Nucleus of MeynertCholinergic Neuronstau ProteinsAgedAged, 80 and overCognitive DysfunctionFemaleGene Expression ProfilingHumansMaleNerve Tissue ProteinsReceptors, Nerve Growth FactorNerve Tissue ProteinsNGFR protein, humanReceptors, Nerve Growth Factortau ProteinsAlzheimer’s diseaseBasal forebrainCholinergicGene expressionNucleus basalisOligomerProfilingTau

Identifiers

PMID41146342
PMCPMC12557935

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.