Evidence map›Paper›PMID 41146304›Full record

ArticleAIDS research and therapy2025

Distribution and efficacy of dolutegravir-based regimens in the main HIV outpatient care in Caracas, Venezuela.

María F Alvarado-Bruzual, Víctor A Mendoza-Merlo, Jesus A Martinez-Torres, Luis J Guerra-Reyes, Rafael N Guevara, Martín Carballo, María Carolyn Redondo, María E Landaeta, David A Forero-Peña

Abstract read
In one paragraph

Article in AIDS research and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

María F Alvarado-Bruzual *Department of Infectious Diseases, Hospital Universitario de Caracas, Caracas, Venezuela.
Víctor A Mendoza-Merlo *Department of Infectious Diseases, Hospital Universitario de Caracas, Caracas, Venezuela.
Jesus A Martinez-TorresBiomedical Research and Therapeutic Vaccines Institute, Caracas, Venezuela.
Luis J Guerra-ReyesDepartment of Infectious Diseases, Hospital Universitario de Caracas, Caracas, Venezuela.
Rafael N GuevaraDepartment of Infectious Diseases, Hospital Universitario de Caracas, Caracas, Venezuela.
Martín CarballoDepartment of Infectious Diseases, Hospital Universitario de Caracas, Caracas, Venezuela.
María Carolyn RedondoDepartment of Infectious Diseases, Hospital Universitario de Caracas, Caracas, Venezuela.
María E LandaetaDepartment of Infectious Diseases, Hospital Universitario de Caracas, Caracas, Venezuela.
David A Forero-PeñaDepartment of Infectious Diseases, Hospital Universitario de Caracas, Caracas, Venezuela. vacter.cv@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Venezuela experienced an interruption in antiretroviral therapy (ART) from 2016 to 2018. Although in early 2019, the dolutegravir (DTG) based regimens were implemented for HIV treatment in Venezuela, few studies have evaluated the efficacy of these regimens. This cross-sectional study describes the utilization, switches and efficacy of ART regimens in the main HIV outpatient care in Venezuela in 2024. Data from 1,998 patient records revealed that the dolutegravir/lamivudine/tenofovir (DTG/3TC/TDF) regimen was predominantly used (85.5%). A high viral suppression rate of over 90% was documented for all DTG-based regimens, with no significant difference found between the main regimen (DTG/3TC/TDF) and its alternatives: DTG/emtricitabine/tenofovir alafenamide (TAF), abacavir/3TC + DTG and, DTG/3TC. Overall, almost all switches (97.1%) were made toward DTG/FTC/TAF. Osteoporosis was the main reason for switching treatments (80.1%).

Indexed as

Anti-HIV AgentsHeterocyclic Compounds, 3-RingHIV InfectionsOxazinesPiperazinesPyridonesAdultAmbulatory CareCross-Sectional StudiesDolutegravirFemaleHumansLamivudineMaleMiddle AgedTenofovirAnti-HIV AgentsDolutegravirHeterocyclic Compounds, 3-RingLamivudineOxazinesPiperazinesPyridonesTenofovirAntiretroviral therapyDolutegravirHIVPLHIVTenofovirVenezuela

Identifiers

PMID41146304
PMCPMC12560526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.