ArticleEuropean journal of medical research2025
Association of free fatty acid receptor 2 expression in peripheral blood monocytes with carotid atherosclerosis.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Short-chain fatty acids promote post-myocardial infarction cardiac repair via FFAR2-dependent suppression of osteoclast-like macrophage differentiation.Basic research in cardiology · 2026Article
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10 authors.
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Abstract
purposeTo investigate the relationship between free fatty acid receptor 2 (FFAR2) expression in peripheral blood monocytes and carotid atherosclerosis (CAS).
methodsBetween November 2023 and June 2024, individuals who underwent carotid ultrasound in the inpatient or outpatient settings of Sichuan Provincial People's Hospital were enrolled in this study. Based on the intima-media thickness (IMT) results from the carotid ultrasound examination, participants were categorized into three groups: the non-CAS group (IMT < 1 mm), the carotid intima-media thickness (cIMT) thickening group (1.0 mm ≤ IMT < 1.5 mm), and the carotid plaque (CP) group (IMT ≥ 1.5 mm with invasion of the lumen or limited intimal thickening higher than 50% of peripheral IMT). The expression levels of FFAR2 in peripheral blood monocytes were detected by flow cytometry. Comparative analyses were conducted on general information and monocyte FFAR2 expression levels across these three groups.
resultsA total of 86 cases were enrolled, comprising 21 cases in the non-CAS group, 21 in the cIMT thickening group, and 44 in the CP group. There were significant statistical differences among the three groups in age, history of hypertension, and Hemoglobin A1c levels (P < 0.05). Specifically, the median (interquartile range) expression levels of FFAR2 in peripheral blood monocytes were 32.04 (17.92, 59.48) × 10
conclusionPeripheral blood monocyte FFAR2 expression appears to be potentially associated with CAS. The upregulation of peripheral blood monocyte FFAR2 expression levels may play a role as a negative feedback regulator, potentially influencing the progression of carotid atherosclerosis, although further research is needed to confirm this hypothesis.
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