Trial reportBMC urology2025
Impact of liberal versus restrictive fluid management on acute kidney ınjury after nephrectomy: a randomised controlled trial with cystatin C evaluation.
Trial report in BMC urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06256120 (Effects of Peroperative Liberal and Restrictive Fluid Regimens on Protection From Postoperative Acute Kidney Injury in Patients Undergoing Partial or Radical Nephrectomy; Randomized Controlled Trial), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Peroperative Liberal and Restrictive Fluid Regimens on Protection From Postoperative Acute Kidney Injury in Patients Undergoing Partial or Radical Nephrectomy; Randomized Controlled Trial
Who cites it
1 citing paper in PubMed.
- [Remimazolam stabilizes hemodynamics during anesthesia induction but fails to reduce renal injury risk following laparoscopic partial nephrectomy: a propensity score-matched retrospective cohort study].Nan fang yi ke da xue xue bao = Journal of Southern Medical UniversityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to compare the effects of liberal versus restrictive intraoperative fluid management strategies on the development of acute kidney injury (AKI) following partial or radical nephrectomy. Additionally, we evaluated the diagnostic performance of serum cystatin C as an early biomarker for AKI.
methodsThis prospective, randomised controlled trial included 73 adults undergoing elective unilateral nephrectomy. Patients were assigned to receive either a liberal (7 mL/kg/h) or restrictive (3 mL/kg/h) intraoperative crystalloid fluid regimen. The primary outcome was the incidence of AKI based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Serum creatinine, blood urea nitrogen (BUN), serum urea, and estimated glomerular filtration rate (eGFR) were measured preoperatively, at 24 and 48th hours postoperatively, and on postoperative day 5. Serum cystatin C was measured preoperatively and at 48th hours. Secondary outcomes included eGFR changes and the predictive accuracy of biomarkers.
resultsAKI occurred significantly more frequently in the restrictive group than in the liberal group (75% vs 40.4%; p = 0.001). The restrictive group experienced a more pronounced reduction in eGFR (- 27.49 ± 20.6 vs - 14.87 ± 16.93 mL/min/1.73 m
conclusionsA liberal intraoperative fluid strategy significantly reduced the incidence of AKI following nephrectomy. Serum cystatin C outperformed creatinine in the early detection of AKI, suggesting a liberal fluid strategy may be preferable to reduce AKI risk, and cystatin C may serve as a useful early AKI biomarker.
trial registrationClinicalTrials.gov Identifier: NCT06256120 (Registered on 26 December 2023).
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