Evidence map›Paper›PMID 41146141›Full record

ArticleBMC oral health2025

Evaluation of custom-made 3D printed polylactic acid/polyethylene glycol scaffolds in soft tissue augmentation: an experimental study in a canine model.

Eman El-Mahalawy, Fatma Ramzy Kamel, Maha R Taalab, Moustafa Aboushleib, Azza Saleh Koura, Wessam M Amin

Abstract read
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In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eman El-MahalawyOral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Alexandria University, Champolion St. Azarita, Alexandria, 21521, Egypt. eman.mahalawy@alexu.edu.eg.ORCID http://orcid.org/0009-0005-1137-095X
Fatma Ramzy KamelOral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Alexandria University, Champolion St. Azarita, Alexandria, 21521, Egypt.ORCID http://orcid.org/0000-0002-3883-9210
Maha R TaalabOral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Alexandria University, Champolion St. Azarita, Alexandria, 21521, Egypt.ORCID http://orcid.org/0000-0003-3586-6747
Moustafa AboushleibDepartment of Dental Materials, Faculty of Dentistry, Alexandria University, Champolion St. Azarita, Alexandria, 21521, Egypt.ORCID http://orcid.org/0000-0003-1934-9440
Azza Saleh KouraDepartment of Oral Biology, Faculty of Dentistry, Alexandria University, Champolion St. Azarita, Alexandria, 21521, Egypt.ORCID http://orcid.org/0009-0005-9020-4086
Wessam M AminDepartment of Materials Science, Institute of Graduate Studies and research, Alexandria University, 163 Horrya Road Elshatby, Alexandria, 21526, Egypt.ORCID http://orcid.org/0009-0008-2851-5141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesHistological and histomorphometric evaluation of the efficacy of custom-made three-dimensional (3D) printed poly-lactic acid (PLA)/ polyethylene glycol (PEG) scaffolds in horizontal soft tissue augmentation compared to connective tissue grafts (CTG) in Mongrel dogs. MATERIALS AND

methodsHorizontal ridge defects were created after tooth extraction in 12 dogs, then randomly allocated to one of the 3 study groups. 1 month after the first surgery, defects were augmented using custom-made 3D printed PLA/PEG scaffolds, or CTG or were left empty. 6 dogs were sacrificed after 1 month post-operatively, and 6 dogs after 3 months. Samples were collected for histologic evaluation.

resultsPLA/PEG and CTG groups successfully augmented soft tissue thickness. Histomorphometrically, fibroblast count (FC) was significantly higher in PLA/PEG group at both time points in comparison to CTG (p = 0.002 and 0.007) and control groups (p = 0.001 and 0.016). Percentage of collagen surface area (%CSA) was significantly higher in PLA/PEG group compared to other groups at 1 month (p = 0.021 and 0.001), however, it was higher in CTG group at 3 months (p = 0.024 and 0.003).

conclusions3D printed custom-made PLA/PEG scaffolds are an easy, effective, and safe method for soft tissue volume augmentation. CLINICAL RELEVANCE: The use of 3D printed scaffolds with properly designed internal structure guides the type of tissues regenerated and eliminates the need for CTG with its higher morbidity and complications.

Indexed as

Alveolar Ridge AugmentationPolyestersPolyethylene GlycolsPrinting, Three-DimensionalTissue ScaffoldsAnimalsConnective TissueDogsModels, AnimalRandom AllocationPolyestersPolyethylene Glycolspoly(lactide)3D printingResorbable polymersScaffoldsSoft tissue augmentationTissue engineering

Identifiers

PMID41146141
PMCPMC12560599

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.