ArticleBMC psychiatry2025
The delta/alpha ratio in sleep EEG increases with the severity of depression in patients over 50 years old.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Psychosocial factors associated with depression and sleep quality in patients with tuberculosis: a multicenter cross-sectional study.Journal of thoracic disease · 2026Article
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Abstract
backgroundThe delta/alpha ratio (DAR) of sleep electroencephalography (EEG) frequency band parameters is closely related to cognitive control in healthy adults, but its role in patients with depression over the age of 50 remains unclear. Currently, a comprehensive and reliable indicator to distinguish the severity of depression in this population is still lacking.
methodsThis study included 88 participants, all of whom underwent overnight polysomnography. Among them, 30 were in the normal control group (Hamilton Depression Rating Scale (HAMD) ≤ 8), 22 in the mild-to-moderate depression group (HAMD ≤ 35), and 36 in the severe depression group (HAMD > 35). We compared demographic characteristics, polysomnographic features, relative EEG spectral power, and their ratios among the three groups.
resultsThe DAR value in the severe depression group was significantly higher than that in the mild-to-moderate depression group. Spearman correlation analysis indicated that the DAR value was positively correlated with depression scores. After adjusting for age, gender, BMI, alcohol, disease duration, and age of onset, logistic regression analysis demonstrated that both the DAR value during Non-Rapid Eye Movement (NREM) sleep (p = 0.017) and Rapid Eye Movement (REM) sleep (p = 0.029) were closely associated with depression. ROC curve analysis revealed that the area under the curve (AUC) for NREM-DAR in depression patients was 0.691, with a sensitivity of 65.7% and a specificity of 81.8%.
conclusionsDAR values strongly correlate with depression severity, suggesting their potential use as a diagnostic marker. NREM-DAR may be a risk factor for severe depression, while REM-DAR may serve as a protective factor.
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