Evidence map›Paper›PMID 41146030›Full record

Observational studyBMC pediatrics2025

Effect of delayed cord clamping on the risk of bronchopulmonary dysplasia in preterm infants with respiratory distress.

Jiajing Ge, Chenhong Wang, Huijia Lin, Guannan Bai, Yanping Xu, Liping Shi, Xiaolu Ma, Zheng Chen

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiajing GeDepartment of NICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Road, Hangzhou, 310052, China.
Chenhong WangDepartment of NICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Road, Hangzhou, 310052, China.
Huijia LinDepartment of NICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Road, Hangzhou, 310052, China.
Guannan BaiDepartment of Child Health Care, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Road, Hangzhou, 310052, China.
Yanping XuDepartment of NICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Road, Hangzhou, 310052, China.
Liping ShiDepartment of NICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Road, Hangzhou, 310052, China.
Xiaolu MaDepartment of NICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Road, Hangzhou, 310052, China.
Zheng ChenDepartment of NICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Road, Hangzhou, 310052, China. chenz@zju.edu.cn.ORCID 0000-0002-0261-8061

Funding

Basic Public Welfare Research Program of Zhejiang Province LGF21H040005Key Program of The Independent Design Project of National Clinical Research Center for Child and Children's Hospital, Zhejiang University School of Medicine Health G20B0007
6 · The paper itself

Abstract

purposeTo assess the incidence of bronchopulmonary dysplasia in preterm infants born at < 32 weeks of gestation who received delayed cord clamping rather than early cord clamping.

methodsDuring this multicenter, prospective, observational cohort study, data of 1283 infants born at < 32 weeks of gestation who received umbilical cord management between January 1, 2020 and December 31, 2021, were collected from 26 tertiary referral neonatal intensive care units in China. The primary outcome was bronchopulmonary dysplasia.

resultsA total of 440 infants (34.3%) received delayed cord clamping. The bronchopulmonary dysplasia rates were 32.5% and 55.6% for infants who received delayed cord clamping and those who received early cord clamping, respectively. After adjusting for potential confounders, the delayed cord clamping group had a lower risk of bronchopulmonary dysplasia (odds ratio [OR], 0.47; 95% confidence interval [CI], 0.35-0.62; P < 0.001). No significant difference in the severity of bronchopulmonary dysplasia was observed between groups (P = 0.09). A subgroup analysis of 227 infants born at < 28 weeks of gestation revealed that 65 (28.6%) received delayed cord clamping, and that 40 (61.5%) of these 65 infants experienced bronchopulmonary dysplasia. After adjusting for potential confounders, the risk of bronchopulmonary dysplasia for the delayed cord clamping group was not decreased (OR, 0.65; 95% CI, 0.30-1.41; P = 0.28).

conclusionDelayed cord clamping independently decreased the risk of bronchopulmonary dysplasia in infants born at < 32 weeks of gestation with moderate-to-severe respiratory distress; however, for those born at < 28 weeks of gestation, this benefit was not observed.

Indexed as

Bronchopulmonary DysplasiaRespiratory Distress Syndrome, NewbornUmbilical Cord ClampingChinaFemaleGestational AgeHumansIncidenceInfant, NewbornInfant, PrematureMaleProspective StudiesTime FactorsBronchopulmonary dysplasiaCohort studyDelayed cord clampingPreterm infant

Identifiers

PMID41146030
PMCPMC12560587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.