ArticleBMC infectious diseases2025
Association of leukocyte telomere length with anti-HBsAg antibody titer in Hepatitis-B recovered patients from the Pakistani population.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study evaluates the leukocyte telomere length and its association with anti-HBsAg antibody titer among the hepatitis-B recovered subjects of the Pakistani population. MATERIALS AND
methodsThis was a retrospective cross-sectional study. In this study, 6414 subjects were screened for quantitative HBV-DNA through qPCR. Six hundred and sixty-eight subjects had a history of chronic hepatitis-B infection while at present they have no HBV-DNA in their blood samples. These subjects were screened for anti-HBsAg antibody through ELISA technique. Among them, 77 subjects developed anti-HBsAg antibody against HBsAg antigen. Of them, 61 subjects' leukocyte telomere length was analyzed through qPCR. In addition, normal healthy control subjects' (n = 18) leukocyte telomere length was also performed.
resultsThe leukocyte Telomere length of chronic Hepatitis-B recovered patients were compared with normal healthy subjects. The mean and standard deviation of the peripheral blood leukocytes' telomere length of the Ct-values between patients and normal control subjects was 11.34 ± 4.12 and 14.79 ± 1.87, respectively. Similarly, the Ct-values for single copy reference gene were 20.03 ± 1.06 and 20.69 ± 0.611 between the chronic Hepatitis-B recovered patients and control subjects. A weak positive association was noted between anti-HBsAg antibody titer with Target/Single copy reference (T/S) ratio and number of base pairs (r = 0.2). In addition, a decline in anti-HBsAg antibody titer was observed with respect to the age of the subjects. There was no significant difference in number of base pairs between the male and female recovered patients. A significant difference between HBV recovered patients and normal control subjects was observed between the T/S ratio and number of base pairs (< 0.0001).
conclusionA marked difference in the T/S ratio and number of base pairs was observed between the hepatitis-B recovered patients and normal control subjects. In chronic hepatitis-B recovered patients, the number of base pairs on each chromosome end were significantly higher as compared with normal control subjects. A weak positive correlation was noted between the T/S ratio and number of base pairs with anti-HBsAg antibody titer. This study shows that hepatitis-B recovered patients have maintained their higher telomere length as compared with the normal control subjects.
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