Evidence map›Paper›PMID 41145998›Full record

ArticleBMC primary care2025

Accelerating the translation of findings from the MoTrPAC study to benefit clinical care: a qualitative analysis.

Katherine A Collins-Bennett, Kandice R Lacci-Reilly, Aylin Aguilar, Jerome L Fleg, Stephanie M George, Joseph A Houmard, Kim M Huffman, Neil M Johannsen, Daniel H Katz, Julia Narendra and 4 more

Abstract read
In one paragraph

Article in BMC primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Katherine A Collins-BennettDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27708, USA. katherine.collins791@duke.edu.
Kandice R Lacci-ReillyDepartment of Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Aylin AguilarDepartment of Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jerome L FlegNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Stephanie M GeorgeOffice of Dietary Supplements, National Institutes of Health, Bethesda, MD, USA.
Joseph A HoumardDepartment of Kinesiology, Human Performance Laboratory, East Carolina University, Greenville, NC, USA.
Kim M HuffmanDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27708, USA.
Neil M JohannsenPreventative Medicine, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Daniel H KatzDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Julia NarendraDepartment of Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Shlomit Radom-AizikUC Irvine Pediatric Exercise and Genomics Research Center, University of California - Irvine, Irvine, CA, USA.
Lauren M SparksTranslational Research Institute AdventHealth, Orlando, FL, USA.
Ashley XiaNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Dan M CooperInstitute for Clinical and Translational Science, University of California - Irvine, Irvine, CA, USA.

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
MoTrPAC Supplemental Funding for MillerU24AR071113 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jon Peter Durda, Karyn A Esser · 2017 to 2026
$28.8M
PAGES: Physical Activity Genomics, Epigenomics/transcriptomics SiteU24DK112331 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STUART C. SEALFON, Martin John Walsh · 2017 to 2026
$18.5M
Stanford/Salk MoTrPAC Site for Genomes, Epigenomes and TranscriptomesU24DK112348 · NIDDK · STANFORD UNIVERSITY · PI Stephen Montgomery, MICHAEL P. SNYDER · 2017 to 2026
$18.4M
Molecular Transducers of Physical Activity Consortium Adult Clinical CenterU01AR071130 · NIAMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUSI, NICOLAS, RASMUSSEN, BLAKE B · 2017 to 2024
$17.7M
ProMoTr: A Proteomics Center for MoTrPACU24DK112349 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI Joshua N. Adkins · 2017 to 2026
$17.5M
The Exercise and Physical Activity Collaborative Team (ExPACT): a Proposed MoTrPAC Clinical CenterU01AR071133 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUFORD, THOMAS W, GOODPASTER, BRET H · 2017 to 2024
$16.7M
A Biochemical Roadmap of Exercise Signaling - Pilot Project for MoTrPAC ConsortiumU24DK112340 · NIDDK · BROAD INSTITUTE, INC. · PI STEVEN A CARR, Clary B Clish · 2017 to 2026
$16.2M
MoTrPAC DXA Quality ControlU01AR071128 · NIAMS · DUKE UNIVERSITY · PI HOUMARD, JOSEPH A, KRAUS, WILLIAM E · 2017 to 2025
$15.2M
Molecular Transducers of Physical Activity Consortium - Colorado Clinical CenterU01AR071124 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI KOHRT, WENDY M · 2017 to 2024
$14.5M
Stanford MoTrPAC Bioinformatics CenterU24OD026629 · OD · STANFORD UNIVERSITY · PI ASHLEY, EUAN A, WHEELER, MATTHEW THOMAS · 2018 to 2023
$13.9M
Michigan MoTrPAC Chemical Analysis Site (MiCAS)U24DK112342 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHARLES F BURANT, CHARLES ROBERT EVANS · 2017 to 2026
$12.6M
NCI NIH HHS P30 CA012197NCI NIH HHS P30CA012197NIAMS NIH HHS U01 AR071124NIAMS NIH HHS U01 AR071128NIAMS NIH HHS U01 AR071130NIAMS NIH HHS U01 AR071133NIAMS NIH HHS U01 AR071150NIAMS NIH HHS U01 AR071158NIAMS NIH HHS U01 AR071160NIAMS NIH HHS U24 AR071113NIA NIH HHS U01 AG055133NIA NIH HHS U01 AG055135NIA NIH HHS U01 AG055137NIA NIH HHS U01 AG070928NIA NIH HHS U01 AG070959NIA NIH HHS U01 AG070960NIDDK NIH HHS U24 DK112326NIDDK NIH HHS U24 DK112331NIDDK NIH HHS U24 DK112340NIDDK NIH HHS U24 DK112341NIDDK NIH HHS U24 DK112342NIDDK NIH HHS U24 DK112348NIDDK NIH HHS U24 DK112349NIH HHS U24 OD026629
6 · The paper itself

Abstract

backgroundThe Molecular Transducers of Physical Activity Consortium (MoTrPAC) is a large-scale research study aimed at elucidating the effects of exercise training on the molecular mechanisms underlying the health benefits of exercise and physical activity. To take a first step toward achieving a goal of rapid dissemination, a qualitative analysis among frontline clinicians was conducted to identify the perceived clinical relevance of exercise research, MoTrPAC discoveries, and optimal ways to disseminate these results to key stakeholders.

methodsA convenience sample of 12 clinicians in internal medicine, family medicine, and emergency medicine agreed to participate in one-on-one interviews. Interviews were conducted over the phone by a member of the Wake Forest Qualitative and Patient-Reported Outcomes (Q-PRO) Shared Resource. Transcripts were stored and coded in ATLAS.ti version 24 software. Two Q-PRO members developed code summaries, which were synthesized into themes and organized using principles of reflexive thematic analysis.

resultsClinicians (n = 12) were predominantly male (n = 7), non-Hispanic White (n = 5), located in California (n = 10), and practiced in a Primary Care/Family Medicine setting (n = 6). Clinicians reported underuse of exercise testing due to provider-level and patient-level barriers. While they valued exercise research, they emphasized the need for clear, practical takeaways and preferred direct dissemination strategies.

conclusionsThese interviews highlighted the variable nature of exercise research dissemination and implementation and are the first steps toward shaping the dissemination of valuable scientific discoveries from the MoTrPAC study.

Indexed as

ExerciseHumansInterviews as TopicMaleQualitative ResearchDisseminationExercise interventionImplementationPhysical activityReflective thematic analysis

Identifiers

PMID41145998
PMCPMC12560478

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.