ArticleNeurogastroenterology and motility2025
Impact of Wild Edible Fruits of Arbutus unedo and Crataegus monogyna on Gut Motility, Contraction, Secretion, and Glucose Regulation.
Article in Neurogastroenterology and motility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundArbutus and hawthorn fruits are commonly utilized in traditional medicine to address various gastrointestinal (GI) ailments. Our primary aim was to individually assess the effects of aqueous extracts from Arbutus unedo (AUAE) and Crataegus monogyna (CMAE) fruits on GI motility, spontaneous jejunal smooth muscle contractility, and hyperglycemia management.
methodsWistar rats were administered loperamide (LOP, 3 mg/kg, b.w.) along with AUAE or CMAE (at doses of 75, 150 and 300 mg/kg, b.w.) or yohimbine (YOH, 2 mg/kg, b.w.). GI transit was evaluated using the charcoal meal test. The impact of both extracts on jejunal secretion and contraction was assessed using the Ussing chamber technique and the isometric transducer. The bioactive constituents of AUAE and CMAE were analyzed via liquid chromatography-high resolution electrospray ionization mass spectrometry (LC-HRESIMS).
resultsAUAE and CMAE comprise bioactive compounds, including phenolic acids, flavonoids, and flavonols, capable of eliciting various intended physiological effects. Both extracts demonstrated a significant and dose-dependent increase in GI transit (77.33%-89.83% and 80.31%-85.54%, respectively) compared to the delayed peristalsis induced by LOP (42.77%) and the accelerated effect of YOH (90.09%). Both extracts induced an increase in the amplitude of spontaneous jejunal contraction with an EC
conclusionThese findings hold promise for the development of novel preventive and pharmacological treatment strategies for GI disorders and diabetes management.
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