Evidence map›Paper›PMID 41145982›Full record

ArticleExperimental physiology2026

Differential contribution of T-type voltage-gated calcium channels to vascular reactivity in the aorta and renal artery of healthy rabbits.

Andrea Suarez, Sol Guerra-Ojeda, Manuel Zarzoso, Marta Serna-García, Jose M Vila, Eva Serna, Maria D Mauricio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrea SuarezDepartment of Physiology, InVas and ModulAhR Groups, Facultat de Medicina i Odontologia, Universitat de Valencia, INCLIVA Biomedical Research Institute, Valencia, Spain.ORCID https://orcid.org/0000-0003-0932-7870
Sol Guerra-OjedaDepartment of Physiology, InVas and ModulAhR Groups, Facultat de Medicina i Odontologia, Universitat de Valencia, INCLIVA Biomedical Research Institute, Valencia, Spain.ORCID https://orcid.org/0000-0003-3018-4683
Manuel ZarzosoDepartment of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Valencia, Spain.ORCID https://orcid.org/0000-0003-3372-4497
Marta Serna-GarcíaDepartment of Dentistry, Faculty of Health Sciences, Universidad Europea de Valencia, Valencia, Spain.ORCID https://orcid.org/0000-0002-4058-2071
Jose M VilaDepartment of Physiology, InVas and ModulAhR Groups, Facultat de Medicina i Odontologia, Universitat de Valencia, INCLIVA Biomedical Research Institute, Valencia, Spain.ORCID https://orcid.org/0000-0001-5265-8072
Eva SernaDepartment of Physiology, InVas and ModulAhR Groups, Facultat de Medicina i Odontologia, Universitat de Valencia, INCLIVA Biomedical Research Institute, Valencia, Spain.ORCID https://orcid.org/0000-0002-2968-3349
Maria D MauricioDepartment of Physiology, InVas and ModulAhR Groups, Facultat de Medicina i Odontologia, Universitat de Valencia, INCLIVA Biomedical Research Institute, Valencia, Spain.ORCID https://orcid.org/0000-0002-7695-2898

Funding

Generalitat Valenciana CIAICO/2023/013Generalitat Valenciana CIAPOS 2023/276
6 · The paper itself

Abstract

T-type voltage-gated calcium channels (VGCCs) are comparatively understudied in large conduit artery function relative to the well-characterized L-type channel subtype. This study investigates the vascular roles of T-type VGCCs in the aorta and renal artery of healthy rabbits using functional reactivity assays and immunofluorescence and further elucidates the interaction between T-type VGCC activity and the nitric oxide (NO) signalling pathway. T-type VGCCs contributed to contractile responses induced by phenylephrine and angiotensin II in both arteries. Moreover, in the renal artery, the contribution of T-type VGCCs in response to phenylephrine increased in the absence of NO and was associated with endothelium-dependent vasodilation. Immunofluorescence analysis revealed co-localization of Ca

Indexed as

AortaCalcium Channels, T-TypeRenal ArteryAngiotensin IIAnimalsEndothelium, VascularMaleNitric OxideNitric Oxide Synthase Type IIIPhenylephrineRabbitsVasoconstrictionVasodilationAngiotensin IICalcium Channels, T-TypeNitric OxideNitric Oxide Synthase Type IIIPhenylephrineaortaendotheliumeNOSrenal arteryT‐type voltage‐gated calcium channelsvascular reactivity

Identifiers

PMID41145982
PMCPMC12949094

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.