Evidence map›Paper›PMID 41145949›Full record

ArticleClinical oral investigations2025

Inflammatory parameters in gingival crevicular fluid and saliva of patients with celiac disease: a comparative analysis.

Arife Sabancı, Ömer Alperen Kırmızıgül, Nazmi Özgen, Halil İbrahim Sabancı, Ahmet Koç, Faruk Dişli, Sedat Yıldız, Kübra Aral

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arife SabancıDepartment of Periodontology, Inonu University, Malatya, Turkey. dtcicekarife@hotmail.com.ORCID 0000-0002-0956-1600
Ömer Alperen KırmızıgülDepartment of Periodontology, Inonu University, Malatya, Turkey.ORCID 0000-0001-5828-8949
Nazmi ÖzgenDepartment of Medical Biology and Genetics, School of Medicine, Inonu University, Malatya, Turkey.ORCID 0000-0003-3326-1293
Halil İbrahim SabancıDepartment of Internal Medicine, Ministry of Health, Battalgazi State Hospital, Malatya, Turkey.ORCID 0000-0003-3439-3933
Ahmet KoçFaculty of Physical Therapy and Rehabilitation, Bingöl University, Bingöl, Turkey.ORCID 0000-0003-3484-2137
Faruk DişliDepartment of Physiology, Faculty of Medicine, Inonu University, Malatya, Turkey.ORCID 0000-0002-0531-2746
Sedat YıldızFaculty of Dentistry, Department of Periodontology, Inonu University, Malatya, 44280, Turkey.ORCID 0000-0002-7872-790X
Kübra AralDepartment of Periodontology, Inonu University, Malatya, Turkey.ORCID 0000-0003-4798-4548

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCeliac disease (CD) is an immune-mediated chronic enteropathy that causes chronic inflammation and has been found to cause oral health problems. The aim of this study was to compare the levels of the inflammatory markers calcium (Ca), caspase-1 and tumor necrosis factor-alpha (TNF-α) in the gingival crevicular fluid (GCF) and saliva of patients with and without celiac disease.

methodsA total of 60 participants were divided into two groups: patients with celiac disease on a gluten diet (C) (n = 30) and systemically healthy controls (H) (n = 30). Full-mouth periodontal measurements, including the gingival index (GI), plaque index (PI), bleeding on probing (BOP), and probing depth (PD), were recorded for all participants. Saliva and GCF samples were collected for analysis of the levels of TNF-α, Ca, and caspase-1 via enzyme-linked immunosorbent assay (ELISA).

resultsSalivary and GCF Ca, caspase-1, and TNF-α levels were not different between the two groups (p > 0.05).

conclusionsOral inflammatory profiles of celiac disease patients on a gluten-free diet show similarities with systemically healthy individuals.

Indexed as

Celiac DiseaseGingival Crevicular FluidSalivaAdultBiomarkersCalciumCase-Control StudiesCaspase 1Diet, Gluten-FreeEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedPeriodontal IndexTumor Necrosis Factor-alphaBiomarkersCalciumCaspase 1Tumor Necrosis Factor-alphaCalciumCaspase 1Celiac diseaseGingival inflammationTumor necrosis factor-alpha

Identifiers

PMID41145949

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.