ArticleNature neuroscience2025
Longitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Trajectories of Response Inhibition Development in Adolescence.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal Mechanisms of Rule Learning.bioRxiv : the preprint server for biology · 2026Article
- Repeatable, low-drift recordings in behaving non-human primates using flexible microelectrodes.bioRxiv : the preprint server for biology · 2026Article
- Cross-species evidence for the refinement of intrinsic neural timescales supporting executive system maturation through adolescence.bioRxiv : the preprint server for biology · 2025Article
- Evaluation of the Psychometric Properties of the Digital Health Literacy Instrument (DHLI-BrA) for Use in Brazilian Adolescents.International journal of environmental research and public health · 2024Article
Corrections and comments
- Update of
Authors and funding
14 authors.
Funding
Abstract
In humans and other primates, adolescence is associated with improvement in cognitive abilities and with changes in brain structure and connectivity. However, how these changes affect neural activity underlying cognitive performance remains unknown. Here we conducted a multilevel, longitudinal study of monkey adolescent neurocognitive development by tracking behavior, neuronal activity and anatomical imaging measures. The trajectory of prefrontal neural activity accounted well for working memory improvements. Complex aspects of activity changed progressively during adolescence, but even simpler attributes, such as baseline rate and variability, had predictive power over behavior. Trajectories of neural activity and cognitive performance were well predicted by maturation of long-distance white matter tracts linking the frontal lobe with other brain areas but, surprisingly, not by decreases in brain volume and thickness, which underlie cognitive changes in humans. Our results link white matter maturation to neural activity changes in adolescent cognitive development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.