SynthesisAesthetic plastic surgery2026
The Use of Poly-4-Hydroxybutyrate (P4HB) Scaffold in Cosmetic Breast Surgery: A Systematic Review and Meta-Analysis.
Synthesis in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Clinical Performance of GalaFLEX® (Poly-4-Hydroxybutyrate) Scaffold Application in Aesthetic and Reconstructive Breast Surgery: A Retrospective Study.Aesthetic plastic surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe P4HB scaffold (GalaFLEX) is an effective tool in breast reconstruction, but its role in cosmetic breast procedures, such as mastopexy, requires further evaluation. We performed a proportions meta-analysis to assess the efficacy and safety of P4HB scaffold use in aesthetic breast surgery.
methodsA systematic literature search was conducted in PubMed, Cochrane Library, and Embase through December 2024 for studies on cosmetic breast surgery using the P4HB scaffold that reported safety and efficacy outcomes. A random-effects model and Freeman-Tukey double arcsine transformation were applied. Statistical analyses were performed using R version 4.1.2.
resultsThree studies with 406 female patients (average age 39) were included, with mastopexy and augmentation-mastopexy being the most common procedures. Pooled analysis showed a delayed wound healing rate of 5.94 per 100 (95% CI: 0.34-16.62%), recurrent implant malposition at 0.47 per 100 (95% CI: 0.00-1.58%), infection at 0.42 per 100 (95% CI: 0.00-2.47%), seroma at 0.31 per 100 (95% CI: 0.00-1.32%), recurrent capsular contracture at 0.18 per 100 (95% CI: 0.00-1.21%), scaffold palpability at 0.11 per 100 (95% CI: 0.00-0.93%), and red breast syndrome at 0.00 per 100 (95% CI: 0.00-1.22%).
conclusionThis meta-analysis suggests that the P4HB scaffold may be a valuable adjunct in aesthetic breast procedures, potentially reducing complications such as implant malposition and capsular contracture, while showing low rates of other complications including delayed wound healing, infection, and seroma. LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Indexed as
Identifiers
41145855What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.