ReviewNature reviews. Neuroscience2026
The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution.
Review in Nature reviews. Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Tunable AMPA receptor function via recurrent evolution of heterotetramers.The Journal of general physiology · 2026Article
- Looking back: tracing the origins of sleep across the animal kingdom.Frontiers in neuroscience · 2026Review
- Spatially resolved gene expression analysis illuminates location-specific functions in the reef-building coral Pocillopora acuta.PloS one · 2026Article
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Authors and funding
2 authors.
Funding
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Abstract
The question of how the first synapses and neurons evolved remains unanswered. Chemical synapses are highly organized functional assemblies, linking two cells between presynaptic and postsynaptic structures. The core set of proteins making these two structures are well conserved in animals, and many of them predate animal evolution. In order to reconstruct the history of how these components came together into a functional unit, it is important to study the conserved and unique functions of synaptic proteins across modern lineages. Here, we provide an overview of the current state of knowledge on the distribution and function of synaptic proteins in early branching animals and their closest protistan relatives. We propose a model in which the evolution of chemical synapses from specialized secretory cells was tightly linked to lifestyle and behaviour in early animals.
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