Evidence map›Paper›PMID 41145834›Full record

ArticleCommunications biology2025

TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream.

Eva Drevet Mulard, Iliass Imam, Pierre-Damien Coureux, Anne Briolay, Laurence Bessueille, Antoine Tarby, Stéphane Balayssac, Sonoko Narisawa, Felix Lecornu, Véronique Gilard and 5 more

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Hypophosphatasia-pathophysiological understanding, preclinical data looking beyond the skeleton, and upcoming treatments.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eva Drevet Mulard *UMR CNRS 5246, ICBMS, University Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Iliass Imam *INSERM, Unit 1033, LYOS, Lyon, France.ORCID http://orcid.org/0009-0004-2098-0752
Pierre-Damien CoureuxMolecular Microbiology and Structural Biochemistry, UMR 5086, CNRS, University Lyon, Lyon, France.
Anne BriolayUMR CNRS 5246, ICBMS, University Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Laurence BessueilleUMR CNRS 5246, ICBMS, University Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Antoine TarbyUMR CNRS 5246, ICBMS, University Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Stéphane BalayssacLaboratoire Softmat, CNRS UMR 5623, Université de Toulouse, Toulouse, France.
Sonoko NarisawaSanford Burnham Prebys, La Jolla, CA, USA.
Felix LecornuINSERM, Unit 1033, LYOS, Lyon, France.ORCID http://orcid.org/0009-0005-7248-4635
Véronique GilardLaboratoire Softmat, CNRS UMR 5623, Université de Toulouse, Toulouse, France.
Sébastien ViolotMolecular Microbiology and Structural Biochemistry, UMR 5086, CNRS, University Lyon, Lyon, France.ORCID http://orcid.org/0000-0001-7749-9207
Jose Luis MillanSanford Burnham Prebys, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1547-2671
Gilles Jean Philippe RautureauUMR CNRS 5246, ICBMS, University Lyon, Université Claude Bernard Lyon 1, Lyon, France.ORCID http://orcid.org/0000-0002-1064-0293
Lionel Ballut *Molecular Microbiology and Structural Biochemistry, UMR 5086, CNRS, University Lyon, Lyon, France.ORCID http://orcid.org/0000-0002-3982-9321
David Magne *UMR CNRS 5246, ICBMS, University Lyon, Université Claude Bernard Lyon 1, Lyon, France. David.magne@univ-lyon1.fr.ORCID http://orcid.org/0000-0002-6511-9390

Funding

Project 4 - Mechanisms of pyrophosphate dysregulationP01AG081167 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI Francesca M Marassi · 2023 to 2026
$13.0M
NIA NIH HHS P01 AG081167
6 · The paper itself

Abstract

Tissue-nonspecific alkaline phosphatase (TNAP) is primarily known for its role in skeletal mineralization, through the hydrolysis of inorganic pyrophosphate (PP

Indexed as

Alkaline PhosphataseEthanolaminesLiverPhosphorylcholineTriglyceridesAnimalsBiological TransportFatty LiverHumansMaleMiceMice, Inbred C57BLMice, KnockoutPhosphorylationAlkaline PhosphataseEthanolaminesPhosphorylcholinephosphorylethanolamineTriglycerides

Identifiers

PMID41145834
PMCPMC12559424

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.