Evidence map›Paper›PMID 41145788›Full record

ArticleBritish journal of cancer2026

Cornulin, a potential prognostic biomarker in head and neck squamous cell carcinoma, acts as an anti-tumour agent by inhibiting cell cycle through upregulation of p18.

Rajandeep Kaur, Anshika Chauhan, Krishan Kumar Saini, Avradeep Datta, Sonal Jangra, Debajyoti Chatterjee, Roshan K Verma, Jaimanti Bakshi, Radhika Srinivasan, Arindam Maitra and 3 more

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Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Rajandeep KaurDepartment of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.ORCID http://orcid.org/0000-0001-9522-1700
Anshika ChauhanDepartment of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.ORCID http://orcid.org/0000-0002-1016-5920
Krishan Kumar SainiCSIR-Central Drug Research Institute, Lucknow, India.
Avradeep DattaDepartment of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Sonal JangraDepartment of Otolaryngology and Head and Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Debajyoti ChatterjeeDepartment of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Roshan K VermaDepartment of Otolaryngology and Head and Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Jaimanti BakshiDepartment of Otolaryngology and Head and Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Radhika SrinivasanDepartment of Cytology & Gynaecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Arindam MaitraBiotechnology Research and Innovation Council-National Institute of Biomedical Genomics, Kalyani, West Bengal, India.
Dipak DattaCSIR-Central Drug Research Institute, Lucknow, India.
Sushmita GhoshalDepartment of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. rtsushmita@gmail.com.ORCID http://orcid.org/0000-0003-0430-7838
Arnab PalDepartment of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India. pal.arnab@pgimer.edu.in.ORCID http://orcid.org/0000-0002-0850-3118

Funding

Council of Scientific and Industrial Research (CSIR) 09/141(0209)/2019Council of Scientific and Industrial Research (CSIR) 09/141(0210)/2019DST | Science and Engineering Research Board (SERB) CRG/2020/001532Indian Council of Medical Research (ICMR) 5/13/74/2020/NCD-III
6 · The paper itself

Abstract

backgroundIn search of salivary biomarkers for Head Neck Squamous Cell Carcinoma (HNSCC), we found Cornulin to be the most downregulated(~10-fold) protein during our previous study, which identified 135 dysregulated proteins in the saliva of the patients. The current study aimed to explore the role(s) of Cornulin in pathophysiology of HNSCC and its translational application.

methodsThe sandwich ELISA and immunohistochemistry assessed the levels of Cornulin in the saliva and primary tumour tissues, respectively, in a cohort of 128 HNSCC patients. The effects of Cornulin modulation were evaluated in-vitro and in-vivo HNSCC models and associated mechanisms were explored by analysis of transcriptomic and proteomic signatures.

resultsCornulin was significantly downregulated in saliva and tumour tissue, which was also associated with tumour differentiation and poor survival. Cell proliferation, migration, viability, and invasion were decreased in Cornulin overexpressed HNSCC cell lines, which was substantiated using in-vivo model, suggesting the anti-tumour role of Cornulin. We identified the probable mechanism through cell cycle arrest in the G1 phase by upregulating p18 and reducing the free intracellular calcium.

conclusionIn conclusion, we report the multifaceted roles of Cornulin in HNSCC, as a potential prognostic biomarker with anti-tumour properties.

Indexed as

Biomarkers, TumorHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckAnimalsCell Line, TumorCell MovementCell ProliferationCyclin-Dependent Kinase Inhibitor p16FemaleGene Expression Regulation, NeoplasticHumansMaleMiceMiddle AgedPrognosisSalivaBiomarkers, TumorCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16

Identifiers

PMID41145788
PMCPMC12764889

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