ReviewCell biology and toxicology2025
Ferroptosis: molecular mechanisms, pathophysiology, and role in pediatric pulmonary diseases.
Review in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Inhibition of the EP300/Notch Signaling Pathway Regulates Proliferation and Apoptosis in Oral Squamous Cell Carcinoma.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Article
- Hyperoxia and iron homeostasis in developing human airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Regulation of Ferroptosis Sensitivity in Hepatocellular Carcinoma Cells by Lysosomal Ion Channels TPC2 and TRPML1.Antioxidants (Basel, Switzerland) · 2026Article
- The RAGE-Ferroptosis Axis Drives Oxidative Stress-Associated Inflammatory Lung Injury in Viral Infection.Antioxidants (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Ferroptosis is a distinct form of programmed cell death characterized by iron-dependent oxidative stress and the accumulation of intracellular reactive oxygen species. This process involves multiple structural alterations, such as rupture of the outer mitochondrial membrane, reduced mitochondrial volume, and the decrease or disappearance of cristae. Additionally, ferroptosis is accompanied by iron overload and heightened lipid peroxidation (LPO). Although ferroptosis has been extensively investigated in various adult diseases, including infectious diseases, neurodegenerative disorders, cancers, and cardiovascular conditions, its role in pediatric respiratory diseases remains unclear. The molecular mechanisms of ferroptosis, particularly iron overload and LPO, are closely linked to the oxidative stress and inflammatory responses commonly observed in respiratory diseases. This review aims to summarize the fundamental processes and regulatory mechanisms of ferroptosis and to explore its potential relevance in pediatric respiratory diseases. By analyzing these mechanisms in depth, we can not only contribute to elucidating the pathophysiological features of pediatric respiratory illnesses but also provide novel insights and therapeutic targets for treatment strategies focusing on ferroptosis, offering new directions for clinical prevention and therapy in respiratory diseases.
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Registered trials
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