Evidence map›Paper›PMID 41145700›Full record

ArticleScientific reports2025

Association between aortic valve calcification and cardiovascular events in patients with chronic kidney disease.

Saki Hayashida, Naoki Haruyama, Hiroyuki Hayashida, Akiko Fukui, Osamu Ohta, Ryota Yoshitomi, Masaru Nakayama

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saki HayashidaDivision of Nephrology, Department of Internal Medicine, NHO Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-Ku, Fukuoka, 810-8563, Japan.
Naoki HaruyamaDivision of Nephrology, Department of Internal Medicine, NHO Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-Ku, Fukuoka, 810-8563, Japan.
Hiroyuki HayashidaDepartment of Cerebrovascular Medicine and Neurology, NHO Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-Ku, Fukuoka, 810-8563, Japan.
Akiko FukuiDivision of Nephrology, Department of Internal Medicine, NHO Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-Ku, Fukuoka, 810-8563, Japan.
Osamu OhtaDivision of Nephrology, Department of Internal Medicine, NHO Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-Ku, Fukuoka, 810-8563, Japan.
Ryota YoshitomiDivision of Nephrology, Department of Internal Medicine, NHO Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-Ku, Fukuoka, 810-8563, Japan.
Masaru NakayamaDivision of Nephrology, Department of Internal Medicine, NHO Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-Ku, Fukuoka, 810-8563, Japan. nakayama51224@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between aortic valve calcification (AVC) and cardiovascular (CV) events across diverse populations including patients with chronic kidney disease (CKD) remains controversial. This study aimed to determine whether AVC is associated with CV events in patients with CKD. In this prospective study, 1,279 participants with CKD were enrolled. A Cox proportional hazard model was applied to determine the association between AVC and CV events. The participants were divided into the following groups according to the number of calcified aortic cusps (CACs): no CACs (n = 922), one CAC (n = 209), and two to three CACs (n = 148). During a median follow-up of 2.9 years, CV events occurred in 185 participants. In multivariable Cox analyses, the hazard ratios (95% confidence intervals) of one CAC and two to three CACs for CV events compared with no CACs were 1.94 (1.32, 2.83) and 2.21 (1.46, 3.33), respectively. In a propensity score-matched cohort, participants with AVC (n = 284) had a significantly higher risk of CV events than those without AVC (n = 284). In CKD, the presence of AVC appears to be an independent risk factor for CV events, and the assessment of AVC is useful in predicting the prognosis.

Indexed as

Aortic ValveAortic Valve StenosisCalcinosisCardiovascular DiseasesRenal Insufficiency, ChronicAgedFemaleHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsAortic valve calcificationCardiovascular eventChronic kidney diseasePropensity score matching

Identifiers

PMID41145700
PMCPMC12559182

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.