Evidence map›Paper›PMID 41145675›Full record

ArticleScientific reports2025

Novel anti-LAG-3 antibody LBL-007 with anti-PD-1 blockade enhances antitumor immunity by promoting T cell-induced apoptosis.

Kewei Qin, Huinan Zhou, Xiaojie Yu, Jianfei Liu, Chenglin Wu, Chen Zhang, Lijun Zhou

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kewei Qin *Central Laboratory, The Sixth Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, 100048, China.
Huinan Zhou *The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Xiaojie YuCentral Laboratory, The Sixth Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, 100048, China.
Jianfei LiuCentral Laboratory, The Sixth Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, 100048, China.
Chenglin WuCentral Laboratory, The Sixth Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, 100048, China.
Chen ZhangThe Fifth Clinical Medical College of Anhui Medical University, Hefei, 230032, Anhui, China.
Lijun ZhouCentral Laboratory, The Sixth Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing, 100048, China. hzzhoulj@126.com.

Funding

Beijing Municipal Natural Science Foundation 7242135National Natural Science Foundation of China 32170933National Natural Science Foundation of China 82202382
6 · The paper itself

Abstract

Immune checkpoint combination therapy, particularly dual LAG-3/PD-1 blockade, demonstrates superior clinical efficacy over monotherapy in cancers like melanoma, yet its mechanistic synergy requires further validation. In this study, we established a cell co-culture model by co-culturing LAG-3

Indexed as

Antigens, CDApoptosisImmune Checkpoint InhibitorsProgrammed Cell Death 1 ReceptorT-LymphocytesAnimalsCell Line, TumorCoculture TechniquesHumansImmunotherapyJurkat CellsLymphocyte Activation Gene 3 ProteinMiceXenograft Model Antitumor AssaysAntigens, CDImmune Checkpoint InhibitorsLag3 protein, humanLymphocyte Activation Gene 3 ProteinPDCD1 protein, humanProgrammed Cell Death 1 ReceptorAntibodyApoptosisCombination blockageImmunotherapyLAG-3

Identifiers

PMID41145675
PMCPMC12559405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.