Articlenpj antimicrobials and resistance2025
Lipopolysaccharide clustering in colistin persistent and resistant bacteria.
Article in npj antimicrobials and resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- An LPS-Immobilized Affinity Screening Platform Identifies Lipopolysaccharide Binding Phytochemicals fromBiology · 2026Article
- Genomic and GWAS-Based Insights into Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2026Article
- Bacteriophages as Antibacterial Agents Against Bovine Pathobionts Associated with Foodborne Human Morbidity.Viruses · 2026Review
- Phage-Based Approaches to ChronicAntibiotics (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Polymyxin antibiotics target lipopolysaccharides (LPS) in Gram-negative bacteria, but persistence and mcr-mediated resistance increasingly compromise their therapeutic efficacy. Here, we use super-resolution localisation microscopy to investigate the nanoscale organisation of LPS and membrane lipids in colistin-persistent Escherichia Pseudomonas aeruginosa. We find that persister cells exhibit heterogeneous LPS and membrane lipid distributions, with localised LPS clustering along the cell envelope, compared to susceptible cells. Unexpectedly, mcr-1-positive E. coli displays a similar LPS clustering phenotype to that of persisters, without altering membrane organisation. These findings suggest that both persistence and resistance involve envelope reorganisation, with increased LPS clustering and remodelling observed in both E. coli and P. aeruginosa. This work reveals a morphological signature of persistence and identifies a shared feature between persistence and resistance in Gram-negative bacteria.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.