ArticleScientific reports2025
Optimizing tissue sampling during medical pleuroscopy for diagnosis of malignant pleural effusion due to lung cancer.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Development and validation of machine learning models based on blood routine tests and tumor markers in early screening of primary bronchogenic lung cancer.Translational lung cancer research · 2025Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cryobiopsy has emerged in recent years as a tool of growing interest in the diagnosis of non-small cell lung cancer (NSCLC). We first conducted the study with the primary objective to compare the quality of cryobiopsies versus conventional forceps biopsies, including diagnostic yield and the feasibility of histological characterization and molecular testing, of malignant pleural effusion (MPE). Prospective study including 14 caucasian patients with MPE due to NSCLC who underwent semirigid pleuroscopy with cryobiopsies. The median biopsy size for conventional flexible forceps and cryoprobe was 2.5 mm (1.5-3.2 mm) and 5.5 mm (3.8-7.6 mm), respectively (p = 0.07). The number of biopsies also differed: flexible forceps: 5 (4-6.25) biopsies vs cryoprobe: 3 (3-4) biopsies(p = 0.01). The tumor/non-tumor ratio in the conventional forceps sample was 2.4 (1.2-5.9), while in the cryoprobe sample, it was 3.6 (1.2-10) (p = 0.09). Only in one case, the samples obtained during semirigid pleuroscopy were insufficient for molecular diagnosis. The incorporation of cryobiopsy into semirigid pleuroscopy has been demostrated to be a effective and safe diagnostic tool. This technique could shortening procedure time and facilitating tissue collection without increasing procedural risks.
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