ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
Hyper-maturity and accelerated aging in the hippocampus of mouse models of neuropsychiatric disorders with anxiety-like behavior.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures.Neuropsychopharmacology reports · 2026Article
- Organ-Specific Regulation of Systemic Aging: Focus on the Brain, Skeletal Muscle, and Gut.Cells · 2026Review
- Cellular heterogeneity and multicellular mechanisms in the pathogenesis of late-life depression: insights from single-cell and spatial multi-omics.Frontiers in immunology · 2026Review
- Abnormal brain network reconfiguration in neuropsychiatric disorders across cognitive decline, Depression, and Schizophrenia.PloS one · 2025Article
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Authors and funding
7 authors.
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Abstract
Proper maturation of neuronal and glial cells in the hippocampus is essential for emotional regulation and cognitive function. While pseudo-immaturity, defined as arrested or reversed development, has been extensively implicated in various neuropsychiatric conditions, the opposite phenomenon, hyper-maturity, remains underexplored. Here, we present transcriptomic evidence of hippocampal hyper-maturity across 17 datasets from 16 mouse models with genetic, pharmacological, or other experimental manipulations, identified through a comprehensive screening of over 260,000 omics datasets. These models were characterized by a pronounced overrepresentation of gene expression changes typically observed during postnatal development and included serotonin transporter knockout mice, glucocorticoid receptor overexpressing mice, and corticosterone-treated mice, models of depression and anxiety, Df(16)A
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