Evidence map›Paper›PMID 41145614›Full record

ArticleScientific reports2025

SPP1

Shaohui Yang, Chenyang Ma, Yibin Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shaohui YangDepartment of Colorectal Surgery, The Affiliated Lihuili Hospital, Ningbo University, 57 Xingning Road, Yinzhou District, Ningbo, 315000, Zhejiang Province, China. doctoryang1980@163.com.
Chenyang MaDepartment of Colorectal Surgery, The Affiliated Lihuili Hospital, Ningbo University, 57 Xingning Road, Yinzhou District, Ningbo, 315000, Zhejiang Province, China.
Yibin ZhaoDepartment of Colorectal Surgery, The Affiliated Lihuili Hospital, Ningbo University, 57 Xingning Road, Yinzhou District, Ningbo, 315000, Zhejiang Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor metastasis is an important risk factor for death in patients with colorectal cancer (CRC). This study aims to explore the effect of CXCL9 and SPP1 (CS) polarity alteration of tumor-associated macrophages (TAMs) on CRC progression and its associated molecular mechanisms. The heterogeneity of cellular subsets between the CRC and Normal groups was analyzed using single-cell RNA sequencing (scRNA-seq) technology. Developmental trajectories of the cellular subsets were plotted using pseudotime analysis, and the differences in enrichment scores among the cellular subsets were analyzed by combining gene set variation analysis (GSVA). Mouse CRC models were constructed, and SPP1

Indexed as

Colorectal NeoplasmsJanus Kinase 2MacrophagesSignal TransductionSTAT3 Transcription FactorTumor-Associated MacrophagesAnimalsApoptosisCell Line, TumorCell ProliferationDisease ProgressionEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansMaleMiceJAK2 protein, humanJak2 protein, mouseJanus Kinase 2STAT3 protein, humanStat3 protein, mouseSTAT3 Transcription FactorColorectal cancerEpithelial-mesenchymal transitionJAK2/STAT3 signaling pathwaySPP1+ macrophagesTumor metastasis

Identifiers

PMID41145614
PMCPMC12559332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.