Evidence map›Paper›PMID 41145609›Full record

ArticleScientific reports2025

Effect of field of view variation on CTP assessment of infarct core and penumbra in acute ischemic stroke.

Chun-Han Liao, Yung-Yin Cheng, Kwo-Whei Lee, Chun-Wen Chen, Ming-Cheng Liu, Shin-Lei Peng, Tsung-Ting Pai, Tzu-Yu Chiu, Chia-Chun Tai, Yi-Jui Liu

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Chun-Han LiaoDepartment of Medical Imaging, Changhua Christian Medical Foundation Yuanlin Christian Hospital, No.456, Juguang Rd, Changhua, 510, Taiwan.
Yung-Yin ChengPh.D. Program in Electrical and Communication Engineering, Feng Chia University, No. 100 Wenhwa Rd, Taichung, 407, Taiwan.
Kwo-Whei LeeDepartment of Medical Imaging, Changhua Christian Medical Foundation Yuanlin Christian Hospital, No.456, Juguang Rd, Changhua, 510, Taiwan.
Chun-Wen ChenDepartment of Radiology, Taichung Armed Forces General Hospital, No.348, Sec.2, Chungshan Rd., Taichung, 411, Taiwan.
Ming-Cheng LiuDepartment of Radiology, Taichung Veterans General Hospital, No.1650, Sec.4, Taiwan Boulevard, Taichung, 407, Taiwan.
Shin-Lei PengDepartment of Biomedical Imaging and Radiological Science, China Medical University, No. 2, Yude Rd, Taichung, 404, Taiwan.
Tsung-Ting PaiDepartment of Radiology, Changhua Christian Medical Foundation Yuanlin Christian Hospital, No.456, Juguang Rd, Changhua, 510, Taiwan.
Tzu-Yu ChiuDepartment of Automatic Control Engineering, Feng Chia University, No. 100 Wenhwa Road, Seatwen, Taichung, 407, Taiwan.
Chia-Chun TaiDepartment of Automatic Control Engineering, Feng Chia University, No. 100 Wenhwa Road, Seatwen, Taichung, 407, Taiwan.
Yi-Jui LiuDepartment of Automatic Control Engineering, Feng Chia University, No. 100 Wenhwa Road, Seatwen, Taichung, 407, Taiwan. erliu@fcu.edu.tw.

Funding

Changhua Christian Hospital 112-CCH-IRP-205National Science and Technology Council 111-2314-B-035-001-MY3
6 · The paper itself

Abstract

The Rapid Processing of Perfusion and Diffusion (RAPID) platform, a validated acute ischemic stroke diagnostic tool, excels in detecting penumbra in large vessel occlusion (LVO) and predicting final infarct volume in recanalized patients. Accurate CT perfusion image quality is essential for assessing infarct core and penumbra volumes. The image spatial resolution is based on the field of view (FOV) in the CT image, while it usually varies depending on the technician's decision. This study examines whether FOV size affects infarct core and penumbra volume measurements in the RAPID system. The study compared arterial input function (AIF), venous output function (VOF) peaks, and time-to-peak (TTP) between large (250 mm) and small (180 mm) FOVs. It also examined the relationship between FOV size and hypoperfusion, infarct core, and mismatch volumes in the RAPID system to assess FOV effects in CTP scans. 62 patients with ischemic infarction were included. The study found no significant differences (p > 0.05) in AIF TTP and VOF TTP between small and large FOVs. However, significant differences were observed in AIF peak (p < 0.001), VOF peak (p < 0.001), hypoperfusion volume (p < 0.001), infarct core volume (p = 0.003), and mismatch volume (p < 0.001) between the two FOV groups. The study concluded that higher spatial resolution CTP images are associated with higher AIF and VOF peaks, a larger hypoperfusion area, a smaller infarct core region, and a larger mismatch volume.

Indexed as

Ischemic StrokeTomography, X-Ray ComputedAgedAged, 80 and overFemaleHumansMaleMiddle AgedCT perfusionHypoperfusionInfarct coreIschemic strokePenumbra

Identifiers

PMID41145609
PMCPMC12559300

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.