Evidence map›Paper›PMID 41145530›Full record

ArticleScientific reports2025

Equivalence of the FCSRT and RAVLT to detect medial Temporal lobe atrophy and tauopathy.

Etienne Aumont, Kelly Amiel, Delphine Oliva Lopez, Jaime Fernandez Arias, Maxime Montembeault, Gleb Bezgin, Brandon J Hall, Lydia Trudel, Tevy Chan, Nesrine Rahmouni and 18 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cognitive screening biases in a secondary prevention Alzheimer's disease clinical trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Etienne Aumont *Department of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada. etienne.aumont@mcgill.ca.
Kelly Amiel *Department of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Delphine Oliva LopezDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Jaime Fernandez AriasDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Maxime MontembeaultMcGill University Research Centre for Studies in Aging, McGill University, 6825 Blvd. LaSalle, Montréal, QC, H4H 1R3, Canada.
Gleb BezginDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Brandon J HallDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Lydia TrudelDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Tevy ChanDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Nesrine RahmouniDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Jenna StevensonDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Stijn ServaesDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Arthur C MacedoDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Seyyed Ali HosseiniDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Paolo VitaliDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Nina Margherita PoltronettiMcGill University Research Centre for Studies in Aging, McGill University, 6825 Blvd. LaSalle, Montréal, QC, H4H 1R3, Canada.
Jesse KlostranecMontreal Neurological Institute, McGill University, 3801 Rue University, Room NW136, Montréal, QC, H3A 2B4, Canada.
Joseph TherriaultDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Andréa L BenedetDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SU/Sahlgrenska, Blå Stråket 15, vån 3, 413 45, Göteborg, Sweden.
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SU/Sahlgrenska, Blå Stråket 15, vån 3, 413 45, Göteborg, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SU/Sahlgrenska, Blå Stråket 15, vån 3, 413 45, Göteborg, Sweden.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SU/Sahlgrenska, Blå Stråket 15, vån 3, 413 45, Göteborg, Sweden.
Thomas K KarikariDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SU/Sahlgrenska, Blå Stråket 15, vån 3, 413 45, Göteborg, Sweden.
Gallen Triana-BaltzerNeuroscience Biomarkers, Johnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Hartmuth C KolbEnigma Biomedical Group, 308 N. Peters Road, Knoxville, TN, 37922, USA.
Serge GauthierDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Yasser Iturria-MedinaDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada.
Pedro Rosa-NetoDepartment of Neurology and Neurosurgery, McGill University, 1033 Pine Ave West, Montréal, QC, H3A 1A1, Canada. pedro.rosa@mcgill.ca.

Funding

Plasma brain-derived tau: a novel Alzheimer’s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in bloodR01AG083874 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas K Karikari · 2023 to 2026
$14.5M
Alzheimer's Association NIRG-12-92090Alzheimer's Association NIRP-12-259245Brain Canada Foundation 34874Canadian Consortium of Neurodegeneration and Aging MOP-11-51-31 -team 1CIHR MOP-11-51-31Fonds de Recherche du Québec - Santé 2020-VICO-279314Fonds de Recherche du Québec - Santé FRQS postdoctoral training scholarshipNIA NIH HHS R01 AG083874
6 · The paper itself

Abstract

In AD research, word-learning tests are often used interchangeably despite using distinct learning protocols. This study verified the equivalence of the Rey Auditory Learning Test (RAVLT) and Free and Cued Selective Reminding Test (FCSRT) when investigating medial temporal lobe (MTL) changes and AD-related tau pathology. We obtained the FCSRT and RAVLT immediate and delayed free recalls from 286 participants aged 51+. We segmented MTL regions to obtain the volume and tau-PET signal using the [

Indexed as

Alzheimer DiseaseCognitive DysfunctionMemory and Learning TestsTauopathiesTemporal LobeAgedAtrophyFemaleHumansIsoquinolinesMaleMental RecallMiddle AgedPositron-Emission Tomographytau ProteinsIsoquinolinesMK-6240tau ProteinsAgingAlzheimer’s diseaseMedial temporal lobeMemory and learning testsTauopathy

Identifiers

PMID41145530
PMCPMC12559241

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.