ArticleNPJ systems biology and applications2025
ROS-induced voltage-gated ion channel expression and electrophysiological remodeling in malignant human cells.
Article in NPJ systems biology and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Mitochondrial oxidative stress and ion-channel suppression reveal a distinct neurotoxic profile of fentanyl analogues in a human neuronal model.Archives of toxicology · 2026Article
- Biomolecular condensates provide a unique environment for redox-mediated protein crosslinking.bioRxiv : the preprint server for biology · 2026Article
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Abstract
Environmental stressors such as radiation, pH shifts, temperature variations, and electromagnetic fields can trigger intracellular oxidative stress, upregulating voltage-gated ion channel (VGIC) gene expression. This paper presents a hybrid modeling framework integrating Hodgkin-Huxley-based electrophysiological simulations with redox-sensitive transcriptional feedback to investigate how reactive oxygen species (ROS) modulate calcium signaling and drive electrophysiological reprogramming. In healthy epithelial cells (MCF-10A), sustained oxidative perturbations induce non-voltage-gated calcium influx, mitochondrial ROS generation, and VGIC transcription, shifting membrane potential from non-excitable to excitable states. Repeated ROS or thermal pulses promote progressive VGIC expression, depolarization, mRNA accumulation, and genomic instability. A Transformer-Long Short-Term Memory (LSTM) model, trained on simulated ROS-VGIC-V
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