Evidence map›Paper›PMID 41145507›Full record

ArticleNature communications2025

Spatial N-glycan rearrangement on α

Massiullah Shafaq-Zadah, Estelle Dransart, Ilyes Hamitouche, Christian Wunder, Valérie Chambon, Cesar A Valades-Cruz, Ludovic Leconte, Nirod Kumar Sarangi, Jack Robinson, Siau-Kun Bai and 12 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Beyond the membrane: rethinking EGFR signaling in physiology and cancer.Cellular and molecular life sciences : CMLS · 2026
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Massiullah Shafaq-Zadah *Chemical Biology of Cancer Unit, Institut Curie, U1339 INSERM, UMR3666 CNRS, PSL Research University, Paris, France. massiullah.shafaq-zadah@curie.fr.ORCID http://orcid.org/0000-0002-7582-8131
Estelle Dransart *Chemical Biology of Cancer Unit, Institut Curie, U1339 INSERM, UMR3666 CNRS, PSL Research University, Paris, France.
Ilyes HamitoucheChemical Biology of Cancer Unit, Institut Curie, U1339 INSERM, UMR3666 CNRS, PSL Research University, Paris, France.
Christian WunderChemical Biology of Cancer Unit, Institut Curie, U1339 INSERM, UMR3666 CNRS, PSL Research University, Paris, France.ORCID http://orcid.org/0000-0001-9091-0080
Valérie ChambonChemical Biology of Cancer Unit, Institut Curie, U1339 INSERM, UMR3666 CNRS, PSL Research University, Paris, France.
Cesar A Valades-CruzChemical Biology of Cancer Unit, Institut Curie, U1339 INSERM, UMR3666 CNRS, PSL Research University, Paris, France.ORCID http://orcid.org/0000-0002-1786-8207
Ludovic LeconteSERPICO Project Team, Inria-UMR144 CNRS Institut Curie, PSL Research University, Paris, France.
Nirod Kumar SarangiSchool of Chemical Sciences and INSIGHT Centre for Data Analytics, Dublin City University, Dublin, Ireland.
Jack RobinsonSchool of Chemical Sciences and INSIGHT Centre for Data Analytics, Dublin City University, Dublin, Ireland.
Siau-Kun BaiChemical Biology of Cancer Unit, Institut Curie, U1339 INSERM, UMR3666 CNRS, PSL Research University, Paris, France.
Raju RegmiPhysique des Cellules et Cancer, Institut Curie, UMR168 CNRS, PSL Research University, Paris, France.ORCID http://orcid.org/0000-0003-4035-0390
Aurélie Di CiccoPhysique des Cellules et Cancer, Institut Curie, UMR168 CNRS, PSL Research University, Paris, France.
Agnès HovasseBioOrganic Mass Spectrometry Laboratory, IPHC UMR 7178, CNRS, Strasbourg University, Strasbourg, France.ORCID http://orcid.org/0000-0001-5241-9688
Richard BartelsLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Ulf J NilssonDepartment of Chemistry, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-5815-9522
Sarah Cianférani-SanglierBioOrganic Mass Spectrometry Laboratory, IPHC UMR 7178, CNRS, Strasbourg University, Strasbourg, France.ORCID http://orcid.org/0000-0003-4013-4129
Hakon LefflerSection MIG (Microbiology, Immunology, Glycobiology), Department of Laboratory Medicine, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0003-4482-8945
Tia E KeyesSchool of Chemical Sciences and INSIGHT Centre for Data Analytics, Dublin City University, Dublin, Ireland.
Daniel LévyPhysique des Cellules et Cancer, Institut Curie, UMR168 CNRS, PSL Research University, Paris, France.ORCID http://orcid.org/0000-0002-8949-4072
Stefan RaunserDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.ORCID http://orcid.org/0000-0001-9373-3016
Daniel RodererLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany. roderer@fmp-berlin.de.ORCID http://orcid.org/0000-0002-7276-3467
Ludger JohannesChemical Biology of Cancer Unit, Institut Curie, U1339 INSERM, UMR3666 CNRS, PSL Research University, Paris, France. ludger.johannes@curie.fr.ORCID http://orcid.org/0000-0002-2168-0004

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-10-IDEX-0001-02Agence Nationale de la Recherche (French National Research Agency) ANR-19-CE13-0001-01Agence Nationale de la Recherche (French National Research Agency) ANR-20-CE15-0009-01Agence Nationale de la Recherche (French National Research Agency) ANR-22-CE11-0030-03Agence Nationale de la Recherche (French National Research Agency) DALLISH-ANR-16-CE23-0005Fondation ARC pour la Recherche sur le Cancer (ARC Foundation for Cancer Research) ARCPGA2024110009062_9628Fondation pour la Recherche Médicale (Foundation for Medical Research in France) EQU202103012926Mizutani Foundation for Glycoscience (Mizutani Foundation) 200014Science Foundation Ireland (SFI) 14/IA/2488Science Foundation Ireland (SFI) 19/FFP/6428
6 · The paper itself

Abstract

Membrane glycoproteins frequently adopt different conformations when altering between active and inactive states. Here, we discover a molecular switch that exploits dynamic spatial rearrangements of N-glycans during such conformational transitions to control protein function. For the conformationally switchable cell adhesion glycoprotein α

Indexed as

EndocytosisGalectin 3Integrin alpha5beta1PolysaccharidesAnimalsBlood ProteinsGalectinsGolgi ApparatusHumansModels, MolecularProtein ConformationProtein MultimerizationBlood ProteinsGalectin 3GalectinsIntegrin alpha5beta1LGALS3 protein, humanPolysaccharides

Identifiers

PMID41145507
PMCPMC12559291

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.