Evidence map›Paper›PMID 41145492›Full record

ArticleScientific reports2025

Ventilatory inefficiency limits 6-min walked distance in systemic sclerosis-associated interstitial lung disease.

Marco Vicenzi, Gaël Deboeck, Chiara Bellocchi, Lorenzo Beretta, Eleonora Tobaldini, Stefano Carugo, Nicola Montano, Gabriel Dias Rodrigues

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marco VicenziDepartment of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, 20122, Italy.
Gaël DeboeckResearch Unit in Rehabilitation Sciences, Faculty of Human Movement Science, Université Libre de Bruxelles, Brussels, 1070, Belgium.
Chiara BellocchiDepartment of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, 20122, Italy.
Lorenzo BerettaDepartment of Internal Medicine, Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda, Milan, 20122, Italy.
Eleonora TobaldiniDepartment of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, 20122, Italy.
Stefano CarugoDepartment of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, 20122, Italy.
Nicola MontanoDepartment of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, 20122, Italy.
Gabriel Dias RodriguesDepartment of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, 20122, Italy. gabriel.dias@unimi.it.

Funding

Gruppo Italiano per la Lotta alla Sclerodermia Bando giovani ricercatori 2022Ministero della Salute,Italy Current research IRCCS
6 · The paper itself

Abstract

Systemic sclerosis-associated interstitial lung disease (SSc-ILD) impacts cardiopulmonary systems and exercise capacity serves as a marker of disease severity. While the six-minute walking test (6MWT) is widely used to assess physical performance, its limitations to assess the cardiopulmonary function remain unresolved in SSc-ILD patients. This study aimed to investigate cardiorespiratory adaptations during the 6MWT, hypothesizing that ventilatory inefficiency is related to exercise capacity in SSc-ILD patients. We recruited 23 female SSc-ILD patients and 13 age- and sex-matched healthy controls (HC). Inclusion criteria included SSc diagnosis (limited or diffuse cutaneous subset) with mild-to-moderate associated ILD. Participants performed 6MWT with combined cardiopulmonary exercise testing (CPET) assessment using a wearable metabolic system to measure ventilatory and gas exchange parameters, including minute ventilation (VE), respiratory frequency (Rf), tidal volume (Vt), and ventilatory equivalent for CO

Indexed as

Lung Diseases, InterstitialScleroderma, SystemicWalkingAdultAgedCase-Control StudiesExercise TestExercise ToleranceFemaleHumansMaleMiddle AgedWalk TestCardiopulmonary exercise testingGas exchangeInterstitial lung diseaseSystemic sclerosisVentilatory equivalents

Identifiers

PMID41145492
PMCPMC12559357

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.